口腔颌面部鳞癌SNCG、MMP-9的表达及其临床意义

›› 2014, Vol. 5 ›› Issue (2): 77-80.

口腔颌面部鳞癌SNCG、MMP-9的表达及其临床意义

薛昌敖¹,张建华²,刘炜²,吴煜农³

1. 南京医科大学附属南京第一医院口腔科
2. 南京医科大学附属南京第一医院
3. 南京医科大学口腔医学研究所

收稿日期:2014-04-08 修回日期:2014-05-19 出版日期:2014-06-25 发布日期:2014-06-23
通讯作者: 薛昌敖 E-mail:xuechangao@126.com
基金资助:
南京市科技局科技发展指导性计划基金资助项目

Expression of SNCG and MMP-9 in oral and maxillofacial carcinoma and its clinical significance

Received:2014-04-08 Revised:2014-05-19 Online:2014-06-25 Published:2014-06-23

摘要/Abstract

摘要： 目的：探讨神经突触核蛋白-γ（synuclein gamma，SNCG）及基质金属蛋白酶-9（matrix metalloproteinase-9，MMP-9）在鳞状细胞癌及癌旁组织的表达，分析其与肿瘤的临床及病理特征相关性。方法：采用免疫组化EnVision二步法检测150例鳞状细胞癌及癌旁组织中SNCG及MMP-9的表达。结果：口腔颌面部鳞癌组织中的SNCG及MMP-9的阳性率分别为78.0%（117/150）及68.68%（103/150），而癌旁组织中SNCG及MMP-9的阳性率分别为8.0%（11/150）及14.0%（21/150），均有显著性差异（P<0.001）。低分化、中分化肿瘤的SNCG及MMP-9的表达阳性率显著高于高分化肿瘤中的阳性率（P<0.001），然而低分化与中分化肿瘤之间SNCG及MMP-9的表达阳性率无显著性差异（P＞0.05）。肿瘤分期分析结果显示，Ⅲ～Ⅳ期SNCG及MMP-9的表达阳性率显著高于Ⅰ～Ⅱ期，有显著性差异（SNCG：χ2＝4.20，P＝0.041；MMP-9：χ2＝26.66，P＝0.000）。转移的肿瘤组织中的SNCG及MMP-9的表达阳性率分别为90.77%和93.85%，高于其在无转移的肿瘤组织表达阳性率，有显著性差异（SNCG：χ2＝10.09，P＝0.001；MMP-9：χ2＝33.80，P＝0.000）结论：SNCG、MMP-9在与口腔颌面部鳞癌中呈现高表达，与肿瘤的病理与临床分级、分期呈正相关，提示检测口腔颌面部鳞癌组织中SNCG及MMP-9的表达可以为肿瘤的病情进展和预后判断提供依据。

Abstract: Objective： To analyze the correlation between synuclein gamma (SNCG) and matrix metalloproteinase-9 (MMP-9) and the clinicopathological features of tumor,we investigated the expression of SNCG and MMP-9 in oral and maxillofacial carcinoma and its adjacent tissues. Methods：Immunohistochemistry method was used to detect the expression of SNCG and MMP-9 in oral and maxillofacial carcinoma and its adjacent tissues. Results：The incidence rate of SNCG and MMP-9 in oral and maxillofacial carcinoma was 78.0% (117/150) and 68.68%(103/150), respectively. While that of SNCG and MMP-9 in its adjacent tissues was 8.0%(11/150) and 14.0%(21/150), respectively. There were significantly differences in SNCG and MMP-9 between them(P<0.001). The incidence rates of SNCG and MMP-9 were higher in poorly or medium differentiated (P<0.001). However, the expression of SNCG and MMP-9 between poorly differentiated and well differentiated carcinoma had no significant difference. According to stages, the incidence rates of SNCG and MMP-9 in Ⅲ-Ⅳ period were significantly higher than those inⅠ-Ⅱ period, and there were significant difference (SNCG: χ2＝4.20, P＝0.041; MMP-9: χ2＝26.66, P＝0.000). The expression of SNCG and MMP-9 in metastatic tumor were higher (SNCG: 90.77%；MMP-9:93.85% ) than that in non-metastatic tumor (SNCG: 68.24%; MMP-9: 49.41%), and there were significant difference(SNCG: χ2＝10.09, P＝0.0014; MMP-9: χ2＝33.80, P＝0.000). Conclusions：The excessive expression of SNCG and MMP-9 in oral and maxillofacial carcinoma,which was positively associated with the pathologic process, differentiation degree of carcinoma, and TNM stages of tumor.The expression of SNCG and MMP-9 are expected to be the marker in the tumor of oral and maxillofacial carcinoma for the judgment of advancement and prognosis.

薛昌敖张建华刘炜吴煜农. 口腔颌面部鳞癌SNCG、MMP-9的表达及其临床意义[J]. , 2014, 5(2): 77-80.

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