Th17/Treg失衡与牙周炎的研究进展

›› 2014, Vol. 5 ›› Issue (4): 199-201.

Th17/Treg失衡与牙周炎的研究进展

孙文韬,束蓉,谢玉峰

上海交通大学医学院附属第九人民医院

收稿日期:2014-11-20 修回日期:2014-12-03 出版日期:2014-12-25 发布日期:2015-01-06
通讯作者: 束蓉 E-mail:shurong123@hotmail.com

Imbalance of Th17 cells and regulatory T cells in periodontitis

Received:2014-11-20 Revised:2014-12-03 Online:2014-12-25 Published:2015-01-06

摘要/Abstract

摘要： 辅助性T细胞17（T-helper 17 cell，Th17）具有促进炎症反应，加重牙槽骨破坏等作用，其主要分泌的促炎细胞因子为白细胞介素（interleukin，IL）-17。调节性T细胞（regulatory T cell，Treg）则可以分泌IL-10和转化生长因子β（transforming growth factor β，TGF-β），抑制炎症反应，并能通过细胞-细胞接触的方式抑制Th17细胞的功能。目前认为Th17/Treg及其分泌的细胞因子失衡在牙周炎的发生发展中起重要作用，但Th17/Treg失衡在牙周炎发生发展中的作用和机制尚不明确。本文就Th17细胞、Treg细胞对牙周炎的作用以及Th17/Treg失衡对牙周炎发生发展的影响作一综述。

Abstract: Periodontitis is a human oral chronic infectious diseases. The recent studies indicate that the imbalance between Th17/Treg cells and their cytokines play an important role in the development of periodontitis. Th17 cells promote inflammation and cause alveolar bone destruction, IL-17 is the main effector of Th17 cells. Treg cells secrete IL-10 and TGF-β, which can suppress inflammation. And Tregs can suppress the function of Th17 cells by cell-cell contacting. But the role and mechanism Th17/Treg imbalance in the development of periodontitis is not clear. This review highlights the role of Th17 cells and Treg cells in periodontitis, and the influence that Th17/Treg imbalance brings to the initiation development of periodontitis.

孙文韬束蓉谢玉峰. Th17/Treg失衡与牙周炎的研究进展[J]. , 2014, 5(4): 199-201.

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