Abstract: Objective： To study the effect of sodium ferulate on periodontal tissue microcirculation of periodontitis with diabetes in rats. Methods： A self-constructed rat model of periodontitis with diabetes was used to detect gingival bleeding index, degrees of the loosening and alveolar bone resorption after intervention with sodium ferulate for 1 month, 3 months and vascular endothelial growth factor (VEGF) inhibitor (as positive control). The pathological condition of rat periodontal tissue was detected by HE staining. The vascular permeability of the gingiva was detected by vascular permeability staining； The expression of VEGF and CD34 in the periodontal tissues of each group was detected by immunohistochemistry, then the microvessel density (MVD) was calculated. Results： The gingival bleeding index and loose degrees were significantly reduced after the intervention of sodium ferulate, and the degree of alveolar bone loss was improved, whose effect was more obviously over time with the intervention. HE staining results showed that after the intervention of sodium ferulate, the inflammatory cells in the gingival tissues were significantly reduced, and the periodontal ligaments were arranged neatly, even osteoblasts were observed. The results of vascular permeability staining showed that the vascular permeability of the gingiva was significantly reduced after the intervention of sodium ferulate compared with the non-intervention group. The results of immunohistochemistry showed that the MVD count was significantly decreased after sodium ferulate intervention, and the VEGF positive cells were significantly reduced and the staining was weakened in the rats’ gingiva. The effect of VEGF inhibitor is the same as the results of intervention of sodium ferulate after 3 months. Conclusions： Sodium ferulate can improve the periodontal tissue microcirculation of periodontitis with diabetes by inhibiting the expression of VEGF in periodontal tissues.