唾液腺肿瘤WHO新分类（2017）有哪些新变化？

摘要/Abstract

摘要： 唾液腺肿瘤是口腔颌面部常见的肿瘤之一，具有独特的临床病理特征。2017 年第 4 版 WHO《头颈部肿瘤病理学和遗传学分类》中对唾液腺肿瘤的组织学分类及其分子病理特征进行了更新和补充，本文着重介绍新版WHO《头颈部肿瘤病理学和遗传学分类》中唾液腺肿瘤的更新和变化部分。

关键词: 唾液腺肿瘤, WHO新分类, 临床病理, 分子病理

周传香李铁军. 唾液腺肿瘤WHO新分类（2017）有哪些新变化？[J]. 口腔生物医学, 2020, 11(3): 137-143.

参考文献 52

[1]	El-Naggar AK, Chan JKC, Grandis JR, et al.WHO classification of head and neck tumours [M]. Lyon: IARC Press, 2017.
[2]	Skálová A, Vanecek T, Sima R, et al.Mammary analogue secretory carcinoma of salivary glands,containing the ETV6-NTRK3 fusion gene: A hitherto undescribed salivary gland tumor entity[J].Am J Surg Pathol, 2010, 34(5):599-608
[3]	Hernandez-Prera JC, Holmes BJ, Valentino A, et al.Macrocystic (Mammary Analogue) Secretory Carcinoma: An Unusual Variant and a Pitfall in the Differential Diagnosis of Cystic Lesions in the Head and Neck[J].Am J Surg Pathol, 2019, 43(11):1483-1492
[4]	Skálová A, Vanecek T, Majewska H, et al.Mammary analogue secretory carcinoma of salivary glands with high-grade transformation: Report of 3 cases with the ETV6-NTRK3 gene fusion and analysis of TP53,β-catenin,EGFR,and CCND1 genes[J].Am J Surg Pathol, 2014, 38(1):23-33
[5]	Levine P, Fried K, Krevitt LD, et al.Aspiration biopsy of mammary analogue secretory carcinoma of accessory parotid gland: Another diagnostic dilemma in matrix-containing tumors of the salivary glands[J].Diagn Cytopathol, 2014, 42(1):49-53
[6]	Griffith CC, Stelow EB, Saqi A, et al.The cytological features of mammary analogue secretory carcinoma: a series of 6 molecularly confirmed cases[J].Cancer Cytopathol, 2013, 121(5):234-241
[7]	Connor A, Perez-Ordo?ez B, Shago M, et al.Mammary analog secretory carcinoma of salivary gland origin with the ETV6 gene rearrangement by FISH: expanded morphologic and immunohistochemical spectrum of a recently described entity[J].Am J Surg Pathol, 2012, 36(1):27-34
[8]	Chiosea SI, Griffith C, Assaad A, et al.Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands[J].Histopathology, 2012, 61(3):387-394
[9]	Bishop JA, Yonescu R, Batista D, et al.Utility of mammaglobin immunohistochemistry as a proxy marker for the ETV6-NTRK3 translocation in the diagnosis of salivary mammary analogue secretory carcinoma[J].Hum Pathol, 2013, 44(10):1982-1988
[10]	Patel KR, Solomon IH, El-Mofty SK, et al.Mammaglobin and S-100 immunoreactivity in salivary gland carcinomas other than mammary analogue secretory carcinoma[J].Hum Pathol, 2013, 44(11):2501-2508
[11]	Skalova A.Mammary analogue secretory carcinoma of salivary gland origin: an update and expanded morphologic and immunohistochemical spectrum of recently described entity[J].Head Neck Pathol, 2013, 7(Suppl 1):S30-S36
[12]	Bishop JA, Yonescu R, Batista D, et al.Most nonparotid “acinic cell carcinomas” represent mammary analog secretory carcinomas[J].Am J Surg Pathol, 2013, 37(7):1053-1057
[13]	Stevens TM, Kovalovsky AO, Velosa C, et al.Mammary analog secretory carcinoma,low-grade salivary duct carcinoma,and mimickers: a comparative study[J].Mod Pathol, 2015, 28(8):1084-1100
[14]	Shah AA, Wenig BM, LeGallo RD, et al.Morphology in conjunction with immunohistochemistry is sufficient for the diagnosis of mammary analogue secretory carcinoma[J].Head Neck Pathol, 2015, 9(1):85-95
[15]	Skálová A, Vanecek T, Simpson RH, et al.Mammary analogue secretory carcinoma of salivary glands: Molecular analysis of 25 ETV6 gene rearranged tumors with lack of detection of classical ETV6-NTRK3 fusion transcript by standard RT-PCR: Report of 4 cases harboring ETV6-X gene fusion[J].Am J Surg Pathol, 2016, 40(1):3-13
[16]	Ito Y, Ishibashi K, Masaki A, et al.Mammary analogue secretory carcinoma of salivary glands: A clinicopathologic and molecular study including 2 cases harboring ETV6-X fusion[J].Am J Surg Pathol, 2015, 39(5):602-610
[17]	Skálová A, Vanecek T, Simpson RH, et al.Mammary analogue secretory carcinoma of salivary glands: Molecular analysis of 25 ETV6 gene rearranged tumors with lack of detection of classical ETV6-NTRK3 fusion transcript by standard RT-PCR: Report of 4 cases harboring ETV6-X gene fusion[J].Am J Surg Pathol, 2016, 40(1):3-13
[18]	Ito Y, Ishibashi K, Masaki A, et al.Mammary analogue secretory carcinoma of salivary glands: A clinicopathologic and molecular study including 2 cases harboring ETV6-X fusion[J].Am J Surg Pathol, 2015, 39(5):602-610
[19]	Patel TD, Vazquez A, Marchiano E, et al.Polymorphous low-grade adenocarcinoma of the head and neck: A population-based study of 460 cases[J].Laryngoscope, 2015, 125(7):1644-1649
[20]	Seethala RR, Johnson JT, Barnes EL, et al.Polymorphous low-grade adenocarcinoma: The University of Pittsburgh experience[J].Arch Otolaryngol Head Neck Surg, 2010, 136(4):385-392
[21]	Nagao T."Dedifferentiation" and high-grade transformation in salivary gland carcinomas[J].Head Neck Pathol, 2013, 7(Suppl 1):S37-S47
[22]	Michal M, Skálová A, Simpson RH, et al.Cribriform adenocarcinoma of the tongue: A hitherto unrecognized type of adenocarcinoma characteristically occurring in the tongue[J].Histopathology, 1999, 35(6):495-501
[23]	Skalova A, Sima R, Kaspirkova-Nemcova J, et al.Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: Characterization of new entity[J].Am J Surg Pathol, 2011, 35(8):1168-1176
[24]	Skalova A, Michal M, Simpson RH.Newly described salivary gland tumors[J].Mod Pathol, 2017, 30(s1):S27-S43
[25]	Skálová A, Gnepp DR, Lewis JS Jr, et al.Newly described entities in salivary gland pathology[J].Am J Surg Pathol, 2017, 41(8):e33-e47
[26]	Slova D, Paniz Mondolfi A, Moisini I, et al.Colonic-type adenocarcinoma of the base of the tongue: A case report of a rare neoplasm[J].Head Neck Pathol, 2012, 6(2):250-254
[27]	Rahimi S, Akaev I, Repanos C, et al.Primary intestinal-type adenocarcinoma of tongue: A case report with immunohistochemical and molecular profiles and review of the literature[J].Head Neck Pathol, 2017, 11(2):186-191
[28]	Kikuchi K, Fukunaga S, Ide F, et al.Primary intestinal-type adenocarcinoma of the buccal mucosa: A case report and literature review[J].Oral Surg Oral Med Oral Pathol Oral Radiol, 2019, 127(2):e61-e70
[29]	Ye P, Gao Y, Wei T, et al.Absence of myoepithelial cells correlates with invasion and metastasis of Carcinoma ex pleomorphic adenoma[J].Int J Oral Maxillofac Surg, 2017, 46(8):958-964
[30]	Griffith CC, Thompson LD, Assaad A, et al.Salivary duct carcinoma and the concept of early carcinoma ex pleomorphic adenoma[J].Histopathology, 2014, 65(6):854-860
[31]	Katabi N, Gomez D, Klimstra DS, et al.Prognostic factors of recurrence in salivary carcinoma ex pleomorphic adenoma,with emphasis on the carcinoma histologic subtype: A clinicopathologic study of 43 cases[J].Hum Pathol, 2010, 41(7):927-934
[32]	Weiler C, Zengel P, van der Wal JE, et al.Carcinoma ex pleomorphic adenoma with special reference to the prognostic significance of histological progression: A clinicopathological investigation of 41 cases[J].Histopathology, 2011, 59(4):741-750
[33]	Smith BC, Ellis GL, Slater LJ, et al.Sclerosing polycystic adenosis of major salivary glandsA clinicopathologic analysis of nine cases[J].Am J Surg Pathol, 1996, 20(2):161-170
[34]	Gnepp DR, Wang LJ, Brandwein-Gensler M, et al.Sclerosing polycystic adenosis of the salivary gland: A report of 16 cases[J].Am J Surg Pathol, 2006, 30(2):154-164
[35]	Skálová A, Gnepp DR, Simpson RH, et al.Clonal nature of sclerosing polycystic adenosis of salivary glands demonstrated by using the polymorphism of the human androgen receptor (HUMARA) locus as a marker[J].Am J Surg Pathol, 2006, 30(8):939-944
[36]	Perottino F, Barnoud R, Ambrun A, et al.Sclerosing polycystic adenosis of the parotid gland: Diagnosis and management[J].Eur Ann Otorhinolaryngol Head Neck Dis, 2010, 127(1):20-22
[37]	Petersson F, Tan PH, Hwang JS.Sclerosing polycystic adenosis of the parotid gland: Report of a bifocal,paucicystic variant with ductal carcinoma in situ and pronounced stromal distortion mimicking invasive carcinoma[J].Head Neck Pathol, 2011, 5(2):188-192
[38]	Canas Marques R, Félix A.Invasive carcinoma arising from sclerosing polycystic adenosis of the salivary gland[J].Virchows Arch, 2014, 464(5):621-625
[39]	Montalli VA, Martinez E, Tincani A, et al.Tubular variant of basal cell adenoma shares immunophenotypical features with normal intercalated ducts and is closely related to intercalated duct lesions of salivary gland[J].Histopathology, 2014, 64(6):880-889
[40]	Weinreb I, Seethala RR, Hunt JL, et al.Intercalated duct lesions of salivary gland: A morphologic spectrum from hyperplasia to adenoma[J].Am J Surg Pathol, 2009, 33(9):1322-1329
[41]	Yu GY, Donath K.Adenomatous ductal proliferation of the salivary gland[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2001, 91(2):215-221
[42]	Chetty R.Intercalated duct hyperplasia: Possible relationship to epithelial-myoepithelial carcinoma and hybrid tumours of salivary gland[J].Histopathology, 2000, 37(3):260-263
[43]	Naunheim MR, Lin HW, Faquin WC, et al.Intercalated duct lesion of the parotid[J].Head Neck Pathol, 2012, 6(3):373-376
[44]	Ellis GL.Lymphoid lesions of salivary glands: Malignant and benign[J].Med Oral Patol Oral Cir Bucal, 2007, 12(7):E479-E485
[45]	Yu GY, Donath K.Adenomatous ductal proliferation of the salivary gland[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2001, 91(2):215-221
[46]	Ma Q, Song H.Diagnosis and management of lymphoepithelial lesion of the parotid gland[J].Rheumatol Int, 2011, 31(7):959-962
[47]	Dunphy CH, Grosso LE, Rodriquez JJ, et al.Bilateral mucosa-associated lymphoid tissue lymphomas of parotid glands: A 13-year interval[J].Mod Pathol, 1996, 9(5):560-565
[48]	Rooper LM, Karantanos T, Ning Y, et al.Salivary secretory carcinoma with a novel ETV6-MET fusion: Expanding the molecular spectrum of a recently described entity[J].Am J Surg Pathol, 2018, 42(8):1121-1126
[49]	Persson F, Andrén Y, Winnes M, et al.High-resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification,rearrangement,and fusion of HMGA2[J].Genes Chromosomes Cancer, 2009, 48(1):69-82
[50]	Skálová A, Weinreb I, Hyrcza M, et al.Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: Molecular analysis of 94 salivary gland carcinomas with prominent clear cell component[J].Am J Surg Pathol, 2015, 39(3):338-348
[51]	Persson M, Andrén Y, Mark J, et al.Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck[J].Proc Natl Acad Sci U S A, 2009, 106(44):18740-18744
[52]	Ferrarotto R, Mitani Y, Diao L, et al.Activating NOTCH1 mutations define a distinct subgroup of patients with adenoid cystic carcinoma who have poor prognosis,propensity to bone and liver metastasis,and potential responsiveness to Notch1 inhibitors[J].J Clin Oncol, 2017, 35(3):352-360

唾液腺肿瘤WHO新分类（2017）有哪些新变化？

What are the new changes in the new WHO classification of salivary gland tumors (2017)?

可视化

摘要/Abstract

引用本文

使用本文

参考文献 52

相关文章 0

编辑推荐

Metrics

本文评价