骨形成蛋白对骨再生中血管化调节作用的研究进展

口腔生物医学 ›› 2025, Vol. 16 ›› Issue (1): 44-47.

骨形成蛋白对骨再生中血管化调节作用的研究进展

周子豪¹,林淑贤¹,张旗²

1. 同济大学附属口腔医院
2. 同济大学口腔医学院同济大学附属口腔医院牙体牙髓科，上海牙组织修复与再生工程技术研究中心

收稿日期:2024-05-27 修回日期:2024-07-11 出版日期:2025-02-25 发布日期:2025-03-07
通讯作者: 张旗 E-mail:qizhang@tongji.edu.cn
基金资助:
牙髓感觉神经通过CGRP/Ramp1轴调控DPSCs定向迁移促牙髓损伤修复及机制研究;牙髓基质细胞线粒体转移在消退素E1介导的牙髓炎症消退及损伤修复中的作用和机制研究

Research progress on the regulatory role of bone morphogenetic protein in angiogenesis during bone regeneration

Received:2024-05-27 Revised:2024-07-11 Online:2025-02-25 Published:2025-03-07

摘要/Abstract

摘要： 骨再生中血管化与成骨密切相关，当血管形成受损时，骨再生的预后较差。目前临床上，骨形成蛋白（BMP）2是使用广泛、成骨效果较好的生长因子，随着对BMP的研究深入，其对血管化的调控作用亦可能是促进骨再生的重要途径之一。本文就近年来BMP对参与骨再生血管化的多种细胞成血管功能的调节作用进行综述，以期为骨再生的临床治疗提供参考和理论依据。

Abstract: Angiogenesis and osteogenesis are intimately linked in bone regeneration. Bone morphogenetic protein 2 (BMP2) is currently the most commonly used BMP in clinical practice. As our understanding of BMP deepens, their regulatory influence on angiogenesis emerges as a crucial pathway in promoting bone regeneration. Hence, this paper provides an overview of BMP's modulation of angiogenic functions in various cell types involved in bone regeneration, aiming to offer insights and theoretical foundations for clinical interventions in bone regenerarion.

周子豪林淑贤张旗. 骨形成蛋白对骨再生中血管化调节作用的研究进展[J]. 口腔生物医学, 2025, 16(1): 44-47.

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