术前血红蛋白、白蛋白和球蛋白比值在口腔鳞癌患者预后中的预测价值

摘要/Abstract

摘要： 目的：探索术前血红蛋白、白蛋白和球蛋白比值（HAGR）在口腔鳞状细胞癌患者预后中的预测价值。方法：收集口腔鳞状细胞癌患者235例；通过卡方检验分析HAGR比值与临床参数之间的相关性；Kaplan-Meier分析用于评估OSCC患者的总体总体生存率及无病生存率；单因素及多因素回归分析影响口腔鳞状细胞癌患者预后的独立危险因素；列线图用于观察患者某一特定时间点的生存概率。结果：HAGR值与患者性别（P=0.001 3）、T分期（P=0.021 8）、BMI值（P=0.024 7）及病理分级（P=0.024 7）显著相关；Kaplan-Meier分析表明HAGR与患者总体生存率（P＜0. 001）及无病生存率相关（P＜0. 001）；多因素回归分析表明T分期（P=0.003）、N分期（P=0.003）及HAGR比值（P=0.009）是影响口腔鳞状细胞癌患者总体生存率的独立预测因子；列线图显示与T分期及N分期相比，HAGR在预测生存率上仍然具有较大的权重。结论：术前HAGR比值可作为预后指标用于预测口腔鳞状细胞癌患者的预后。

关键词: 口腔鳞状细胞癌, HAGR, 预后, 列线图

Abstract: Objective: To explore the predictive value of preoperative hemoglobin, albumin-globulin ratio (HAGR) in the prognosis of patients with oral squamous cell carcinoma (OSCC). Methods: A total of 235 patients with OSCC were enrolled. The correlation between HAGR and clinical parameters was analyzed by chi-square test. Kaplan-Meier analysis was used to evaluate the overall （OS）and disease-free survival rates （DFS）of OSCC patients. Univariate and multivariate regression analysis were used to analyze the independent risk factors affecting the prognosis of OSCC patients. The nomogram was used to observe the survival probability of patients at a specific time point. Results: HAGR value was significantly correlated with gender (P=0.001 3), T stage (P=0.0218), BMI (P=0.024 7) and pathological grade (P=0.0247). Kaplan-Meier analysis showed that HAGR was associated with overall (P＜0. 001) and disease-free survival (P＜0.00 1). Multivariate regression analysis showed that T stage (P=0.003), N stage (P=0.003) and HAGR (P=0.009) were independent predictors of overall survival in patients with oral squamous cell carcinoma. The nomogram showed that HAGR still had a greater weight in predicting survival compared with T stage and N stage. Conclusion: Preoperative HAGR can be used as a prognostic indicator to predict the prognosis of patients with OSCC.

Key words: Oral squamous cell carcinoma, HAGR, Prognosis, nomogram

韩冰张伟俞辉明. 术前血红蛋白、白蛋白和球蛋白比值在口腔鳞癌患者预后中的预测价值[J]. 口腔生物医学, 2025, 16(3): 150-154.

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