›› 2012, Vol. 3 ›› Issue (2): 74-77.

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The effect of BGL2 and XOG1 to Candida albicans biofilm drug resistance

  

  • Received:2012-04-12 Revised:2012-05-18 Online:2012-06-25 Published:2012-06-26

Abstract: Objective:To investigate the relationship between the gene BGL2, XOG1 and Candida albicans biofilm drug resistance. Methods:Candida albicans drug resistance was induced by Fluconazole with gradually increased concentration,and identified by the KONT MIC determination system. RT-PCR and qRT-PCR were used to analyze the expressions of glucan-related genes in Candida albicans SC5314 and the drug resistant strain. Results:The KONT MIC determination system showed the minimal inhibitory concentration (MIC) of the drug resistant strain was more than 128 μg/ml. Compared with the control strain, the expression of XOG1 in the drug resistant strain was significantly reduced(P <0.05), but the expression of BGL2 was not significantly changed. Conclusions:Glucan-related gene XOG1 was related to the resistance of Candida albicans biofilm.