›› 2014, Vol. 5 ›› Issue (4): 206-208.

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Angiogenesis effect of hyaluronan oligosaccharides

  

  • Received:2014-09-03 Revised:2014-11-21 Online:2014-12-25 Published:2015-01-06

Abstract: Oligosaccharides of hyaluronan were able to promote endothelial cell proliferating and induce angiogenesis, the biological activities of o-HA depend on its molecular weight. Studies have shown that the biological functions of o-HA are initiated through cell surface receptors or HA-binding proteins, resulting in signal transduction activation and ultimately angiogenesis. We review the pro-angiogenesis activity of o-HA and the involved functional mechanism.

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