Abstract: Objective：To investigate the effect of simvastatin administration on osseointegration surrounding the implant by establishment of maxillary implant rat model. Methods：Three-month-old female SD rats were randomly divided into control group and oral administration group. The control group was administrated with saline. The other group was administrated with simvastatin. After Titanium implants（0.8 mm×2.0 mm）were put in anterior to the first molar of maxillary, different administration programs were applied and the rats weights and serum concentrations of ALP and BGP were detected at 1, 2 and 4 weeks, respectively. Two weeks after administration, HE staining was used to observe the formation of new bone. After 4 weeks administration, micro-CT was used to observe the bone structure by measuring bone density around the implant. Results： The weight of rats was decreased in simvastatin administration group compared with that of the control group, and the difference was statistically significant (P< 0.05). The data of serum ALP and BGP showed the similar trend with weight (P< 0.05). At 2nd week, HE staining indicated that much more trabecular bone was observed in simvastatin administration rats in contrast with control. At 4th week, the data of all the trabecular bone parameters were increased in simvastatin administration rats, except for Tb.Sp and the difference was statistically significant (P< 0.05). Meanwhile, three-dimensional reconstruction also confirmed the similar results. Conclusions：Simvastatin significantly promotes the formation of new bone around the implant via orally administration.