Abstract: Abstract:Mandibular Condylar Cartilage cells(MCCSs) is the only cell components of Condylar Cartilage, and the growth and metabolish of MCCSs is affected by various cytokine, mechanical stimulation and hormone, among which the influence of estrogen hormone has received much concern of the scholars, it might be one of the factors to cause Temporomandibular Joint Disorder. The researches that the estrogen hormone influences the metabolism of Ariticular Chondrocytes are more intensive. But Condylar Cartilage is fibrocartilage, which differ from Ariticular Chondrocytes. The researches about it are relatively lay behind. This paper will give a summary of the interrelated mechanism about estrogen hormone reconstructe the growth, metabolism and applicability of MCCSs, which will contribute to learning more how the change of estrogen level affect the physiological and pathological change of temporomandibular joint.In the hope of making progress in treating Temporomandibular Joint Disorder.