›› 2017, Vol. 8 ›› Issue (1): 7-10.

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Streptococcus mutans; fluoride-resistant Streptococcus mutans; rpl gene; RpiR family transcriptional regulator; fructose-specific PTS system

  

  • Received:2016-12-27 Revised:2017-02-06 Online:2017-03-25 Published:2017-04-11

Abstract: Objective:To screen EDA gene in a family with X-linked hypohidrotic ectodermal dysplasia and lay a basis for genetic counseling and prenatal diagnosis. Methods:Genomic DNA was isolated from the blood samples of all available family members. All exons of EDA were amplified using polymerase chain reaction (PCR) and then directly sequenced. Results:A missense mutation (c. 1045 G>A) was identified in exon 9 of EDA which changed Ala into Thr in the coding amino acids(p. 349 A>T). Conclusions:This mutation caused X-linked hypohidrotic ectodermal dysplasia in the investigated family.