Abstract: Objective：To observe the effects of resveratrol on the proliferation and osteogenic differentiation of human dental pulp stem cells (hDPSCs) modified by SLA on oxidized stress. Methods：Enzyme digestion was used to isolate cultured human dental pulp derived hDPSCs in vitro. Oxidative stress was induced by hydrogen peroxide (200 μmol/L) for 24 hours. Application of 10 μmol/L resveratrol to hDPSCs was treated with hydrogen peroxide. The effects of resveratrol on the proliferation of hDPSCs after oxidative stress was observed by AlamerBlue method. The effects of resveratrol on the adhesion and morphology of hDPSCs on SLA titanium surface were observed by scanning electron microscopy. The effect of resveratrol on the osteogenic differentiation of hDPSCs on oxidized stress was observed by ALP staining. Results：The proliferation ability of hDPSCs of oxidative stress was significantly lower than that of the normal control group. Resveratrol could significantly increase the proliferation of hDPSCs of oxidative stress and promote the adhesion and morphology change of hDPSCs and the ALP expression on the surface of SLA modified. Conclusions：Resveratrol could promote the proliferation and bone differentiation ability of hDPSCs on the surface of SLA modified titanium.