Abstract: Periodontitis is defined as a chronic inflammation resulting in irreversible destruction of periodontal supporting tissue. In severe cases, reduced periodontal support can lead to tooth loss. A lot of studies have been conducted to investigate true periodontal regeneration----the complete reconstruction of the damaged attachment apparatus.However, these procedures，what have been approved for clinical use,have limited success.For the last two decades,tissue engineering technology,combining cells with scaffolds and bioactive factors,might provide new approaches for periodontal regeneration . To find or prepare a suitable scaffold is the key of periodontal tissue engineering.In this review, we focus on recent studies about scaffolds in the periodontal tissue engineering.