线粒体DNA与牙周炎相关性研究进展

Abstract

Abstract: Periodontitis is a chronic infectious disease with a high incidence rate. Scholars have paid great attention to the study of its immunological mechanism. Mitochondrial DNA (mtDNA) is a major member of damage-associated molecular patterns (DAMPs) and can be involved in activating the innate immune response. In recent years, the relationship between mtDNA and inflammation has become a research hotspot. There are evidences showing mtDNA is involved in the occurrence and development of periodontitis. Besides, many evidences of mtDNA and inflammatory signaling pathways related to periodontitis suggest that mtDNA may play an important role in the inflammation of periodontitis. This review aims to provide clues for the further exploration of the relationship between mtDNA and periodontitis.

Key words: periodontitis, mitochondrial DNA, damage-associated molecular patterns, inflammation

References 36

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Research Progress on Correlation between Mitochondrial DNA and Periodontitis

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