›› 2020, Vol. 11 ›› Issue (1): 36-40.

Previous Articles     Next Articles

Prognostic role of TEAD4 in Oral Squamous Cell Carcinoma and its Effect on cell migration and invasion

  

  • Received:2019-10-23 Revised:2020-02-25 Online:2020-03-25 Published:2020-04-07
  • Contact: Jian-rong -Yang E-mail:m15950686940@163.com

Abstract: Objective: To investigate the expression of TEA domain transcription factor 4 (TEAD4) in oral squamous cell carcinoma (OSCC) and its correlation with clinical pathological parameters and prognosis value, and explore the biological function in OSCC invasion and migration ability. Methods: Immunohistochemistry was assessed to detect TEAD4 expression in 79 primary OSCC sample and 21 normal oral mucosa. The associations between TEAD4 and multiple clinicopathological parameters and prognosis were analyzed. In vivo assay, Western Blot, q-PCR, wound healing assay and Transwell invasion assay were assessed to detect the invasion and migration ability when TEAD4 silencing. Results: Immunohistochemistry data showed that the expression of TEAD4 in OSCC was significantly higher than that in normal oral mucosa (P<0.05). And its expression in OSCC was significantly correlated with cervical lymph node metastasis, clinical stage, and overall survival rate (P<0.05). The invasion and migration ability of Cal27 was impaired when TEAD4 silencing in vivo assay. Conclusions: Our findings reveal that overexpression of TEAD4 correlate with OSCC malignant phenotype of, the prognosis of patients and promoting OSCC cell migration and invasion.

Key words: TEAD4, oral squamous cell carcinoma, cell migration, invasion

CLC Number: