Oral Biomedicine ›› 2021, Vol. 12 ›› Issue (2): 128-131.

Previous Articles     Next Articles

Research Progress on regulation of cell volume by swell1

  

  • Received:2020-10-14 Revised:2021-04-23 Online:2021-06-25 Published:2021-06-25

Abstract: Maintaining the stability of cell volume is an important condition in the process of cell life. Volume regulated anion channel (VRAC) plays an important role in regulating the osmotic pressure inside and outside the cell membrane through organic matter accumulation and inorganic ion exchange. VRAC regulates cell volume and participates in a series of biological and cellular activities such as nervous system, immune system, metabolism, cell migration, proliferation and apoptosis. Recently, studies have confirmed that leucine rich repeat containing protein 8A (IRRC8a, also known as Swell1) and its four homologous family members are an important VRAC and play an important role in the regulation of cell volume. In this paper, we reviewed the structure of Swell1,as well as its effect and mechanism on different cell volume regulation.

Key words: Volume-regulated anion channel, SWELL1, Cell volume regulation