Abstract: Oral implant longevity and function rely on osseointegration and soft tissue integration ,soft tissue barrier protects the underlying hard tissue structures and the implant itself from oral polluted environment, which is of great significance to the long-term stability of the implant and the maintenance of soft tissue aesthetic effects.Implant surface morphology can affect soft tissue integration,the purpose of this review is to introduce the effect of titanium surface nano-morphology on epithelial cells and relevant datas.The differences between nanoscale and microscale implant surface modification were discussed, with emphasis on the methods and understandings to achieve specific functions of epithelial cells through nanotechnology.

Key words: titanium, nanostructure, epithelial cell, dental implant , surface topography