骨髓间充质干细胞线粒体结构和功能在骨损伤修复中的变化和作用

Abstract

Abstract: The function of bone marrow mesenchymal stem cells is the biological basis of bone injury repair. Mitochondria, as the energy factory and signal transmission center of BMSCs, play a role in bone injury repair by regulating the function of BMSCs. The damage of mitochondrial structure and function not only leads to abnormal energy metabolism of BMSCs, but also can release pro-injury signal molecules, resulting in abnormal proliferation and differentiation of BMSCs, thus affecting bone repair. In this paper, the research progress of the role of mitochondrial structure and function in bone injury repair and mitochondrial quality control mechanism in recent years is reviewed, in order to provide reference and theoretical guidance for the clinical treatment of bone injury repair.

Key words: bone injury, bone marrow stromal cells, mitochondrion

CLC Number:

R782.4

References

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Changes and roles of mitochondrial structure and function in bone marrow mesenchymal stem cells in bone injury repair

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