Oral Biomedicine ›› 2023, Vol. 14 ›› Issue (1): 19-22.

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Phenotype analysis on systemic diseases with dentin dysplasia

  

  1. 1. School of Stomatology, the Fourth Military Medical University
    2. State Key Laboratory of Military Stomatology; National Clinical Research Center for Oral Diseases; Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, Clinic of Oral Rare Diseases and Genetic Diseases, The Third Affiliated Hospital of Air Force Military Medical University
    3.
  • Received:2023-01-03 Revised:2023-02-15 Online:2023-03-25 Published:2023-03-29

Abstract: Objective:With systemic diseases accompanied by dentin abnormalities as the objective of this study, to generalize the phenotypes of dentin dysplasia (DD) and to complement the phenotypes of syndromic DD. Methods:The first edition of oral diseases list and PubMed database were searched for the reported cases. Then the dentin-related phenotypes were counted and analyzed. Results:By the end of the year 2021, a total of 59 cases of systemic diseases with DD were searched in hyperphosphatemic familial tumoral calcinosis (HFTC) and Ehlers-Danlos syndrome (EDS). In these cases, beside the corresponding systemic symptoms, the phenotypes of dentin abnormalities were pulp volume reduction (55.9%), pulp calcification (50.8%) and root dysplasia (35.6%), which were similar to the phenotypes of DD. However, some dentin abnormalities were different from typical DD, such as tooth discoloration (8.5%) and root elongation (18.6%). Conclusions:Systemic diseases with dentin abnormalities often have characteristic DD, typical or atypical. Dentin abnormalities can serve as an important indicator.