Abstract: Objective: To evaluate the effects of the thickness of tooth preparation, abutment color, and resin cement shade on the color of digital-guided glass full-crown restoration for incisor with different thickness of crown. Methods: The all-ceramic crown restorations were randomly divided into 18 groups according to three factors of the thickness of tooth preparation (1.0 mm and 1.5 mm), abutment color (IPS-ND2, ND5, ND8) and resin cement shade (Translucent-TR, B0.5 opaque-B0.5, White opaque-WO), with 10 specimens in each group. The monothetic glass ceramic crown was fabricated by CAD/CAM. The abutments were made using IPS nature die resin according to different colors as designed. The all-ceramic crowns in each group were temporally fixed on the resin abutment with the try-in paste for the color assessment using VITA Easyshade spectrophotometer and the results were recorded by L*a*b* system. Results: The thickness of tooth preparation, abutment color and resin cement shade and their interaction all showed a significant effect on the color of digital-manufactured monothetic glass ceramic crown for incisor (P<0.001). Conclusions: In case of restorationwith all ceramic crown that fabricated by CAD/CAM technique in anterior teeth, clinicians should make an optimal design of the tooth preparation and the thickness of the crown, according to the different abutment color. Furthermore, a resin cement with proper color should be selected for cementation in order to achieve an aesthetic and durable restoration.assessment using VITA Easyshade spectrophotometer and the results were recorded by L*a*b* system. Results: The thickness of tooth preparation, abutment color and resin cement shade and their interaction all showed a significant effect on the color of digital- manufactured monothetic glass ceramic crown (P<0.001). Conclusion: In case of restoration with all ceramic crown that fabricated by CAD/CAM technique in anterior teeth, clinicians should make an optimal design of the tooth preparation and the thickness of the crown, according to the different abutment color. Furthermore, a resin cement with proper color should be selected for cementation in order to achieve an aesthetic and durable restoration.