Abstract: The ultimate goal of periodontal treatment was to reconstruct the structure and function of cementum-periodontal ligament-alveolar bone complex. However, how to precisely regulate the mineralization of different periodontal tissues was the key point and main difficulty in achieving periodontal tissue regeneration. Studies had shown that pyrophosphate (PPi) and its related regularoty factors could regulate the mineralization of alveolar bone, cementum and periodontal ligament. In this review, we analysed and summarized the research progress of the regulation of PPi and its related regulatory factors on periodontal supporting tissue mineralization and try to provide a theoretical basis for periodontal regeneration.

Key words: pyrophosphate, mineralization, alveolar bone, cementum, periodontal ligament