低氧与牙周炎：发生发展和治疗新策略

Abstract

Abstract: Enhanced metabolism of periodontal tissues, microcirculatory disturbances, and proliferation of periodontal bacteria within periodontal pockets resulting in a hypoxic microenvironment are significant pathophysiological features of periodontitis. Important risk factors for the occurrence and progression of periodontitis include high-altitude residence, obstructive sleep apnea syndrome, smoking, which induce low oxygen levels in periodontal tissues and periodontal pockets. The interaction between hypoxia and periodontitis promotes the occurrence and development of periodontitis. This review explores the interaction between hypoxia and periodontitis, as well as the latest research progress on treatment strategies based on the hypoxic microenvironment within periodontal pockets, providing insights for the prevention and treatment of periodontitis.

CLC Number:

R781.4

References 55

[1]	Song Z C, Zhou W, Shu R, et al.Hypoxia induces apoptosis and autophagic cell death in human periodontal ligament cells through hif-1a pathway[J].Cell Proliferat, 2012, 45(3):239-248
[2]	Koh M Y, Powis G.Passing the baton: the hif switch[J].Trends Biochem Sci, 2012, 37(9):364-372
[3]	Mettraux G R, Gusberti F A, Graf H.Oxygen-tension (po2) in untreated human periodontal pockets[J].J Periodontol, 1984, 55(9):516-521
[4]	Xiao X W, Yu C, Wai K L.Role of the hypoxia-inducible factor in periodontal inflammation[J].Hypoxia and Human Diseases，Jing Z, Chi Z, Rijeka:IntechOpen,, 2017, 15(-):---
[5]	Hirai K, Furusho H, Hirota K, et al.Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss[J].Int J Oral Sci, 2018, 10(2):12--
[6]	Celik D, Kantarci A.Vascular changes and hypoxia in periodontal disease as a link to systemic complications[J].Pathogens, 2021, 10(10):1280--
[7]	蒲东全，刘鲁川，宋远雄，等.不同海拔高度部队驻军官兵牙周健康调查[J].牙体牙髓牙周病学杂志, 2009, 19(01):35-38
[8]	Rams T.Global epidemiology of periodontal diseases: an overview[J].Periodontol, 2002, 29(-):7-10
[9]	Zheng W, Shi W, Ma D, et al.Loss of proliferation and differentiation capacity of aged human periodontal ligament stem cells and rejuvenation by exposure to the young extrinsic environment[J].Tissue Eng Part A, 2009, 15(-):2363-2371
[10]	Lu Y, Wahl L.Oxidative stress augments the production of matrix metalloproteinase-1,cyclooxygenase-2,and prostaglandin e2 through enhancement of nf- b activity in lipopolysaccharide-activated human primary monocytes[J].J Immunol (Baltimore, Md.), 2005, 175(-):5423-5429
[11]	Seo W, Cho E, Thomas R, et al.The association between periodontitis and obstructive sleep apnea: a preliminary study[J].J Periodontal Res, 2012, 48(4):500-6
[12]	Chen Y, Metz J, Gao H, et al.Association between obstructive sleep apnea and periodontitis in chinese male adults: a cross-sectional study[J].J Prosthet Dent, 2021, 130(1):80-86
[13]	柴晶，王小琴，苗伟.阻塞性睡眠呼吸暂停综合征对大鼠牙周组织影响的研究[J].国际口腔医学杂志, 2014, 41(06):635-638
[14]	Petersen P, Ogawa H.The global burden of periodontal disease: towards integration with chronic disease prevention and control[J].Periodontol, 2012, 60(-):15-39
[15]	Leite F, Nascimento G, Scheutz F, et al.Effect of smoking on periodontitis: a systematic review and meta-regression[J].Am J Prev Med, 2018, 54(6):831-841
[16]	Turnbull B.Smoking and periodontal disease. A review.[J].J N Z Soc Periodontol, 1995, -(79):10-15
[17]	Bozyel B, Kalkan A, ?zdemir B.The role of hypoxia in periodontal diseases[J].GUHES, 2021, 3(-):885997--
[18]	Ng K, Li J, Ng K M, et al.Expression of hypoxia-inducible factor-1α in human periodontal tissue[J].J Periodontol, 2011, 82(1):136-141
[19]	Zhu R, Mi X, Li Y.Effects of hypoxic environment on periodontal tissue through the ros/txnip/nlrp3 inflammasome pathway[J].Biomed Res Int, 2022, -(-):7690960--
[20]	Ozcan E, Saygun N I, Serdar M A, et al.Non-surgical periodontal therapy reduces saliva adipokine and matrix metalloproteinase levels in periodontitis[J].J Periodontol, 2016, 87(8):934-943
[21]	Chaparro A, Lozano M, Gaedechens D, et al.Exploring the expression of pro-inflammatory and hypoxia-related microrna-20a,microrna-30e,and microrna-93 in periodontitis and gingival mesenchymal stem cells under hypoxia[J].Int J Mol Sci, 2022, 23(18):10310--
[22]	Klokkevold P R, Newman M G, Takei H H, et al.Newman and carranza' s clinical periodontology[M]. 13th Edition. Holland: Elsevier, 2018.
[23]	Talla U, Bozonet S M, Parker H A, et al.Prolonged exposure to hypoxia induces an autophagy-like cell survival program in human neutrophils[J].J Leukocyte Biol, 2019, 106(6):1367-1379
[24]	Liu F, Liu Y, Lui V C H, et al.Hypoxia modulates lipopolysaccharide induced tnf-α expression in murine macrophages[J].Exp Cell Res, 2008, 314(6):1327-1336
[25]	Zhao L, Wu Y, Tan L, et al.Coculture with endothelial cells enhances osteogenic differentiation of periodontal ligament stem cells via cyclooxygenase-2prostaglandin e2vascular endothelial growth factor signaling under hypoxia[J].J Periodontol, 2013, 84(12):1847-1857
[26]	Li Q, Luo T, Lu W, et al.Proteomic analysis of human periodontal ligament cells under hypoxia[J].Proteome Sci, 2019, 17(1):3--
[27]	侯建霞.低氧对人牙周膜干细胞骨向分化影响的实验研究[J].中华口腔医学杂志, 2009, 44(9):543-547
[28]	Xiao Z, Han Y, Zhang Y, et al.Hypoxia-regulated human periodontal ligament cells via wntβ-catenin signaling pathway[J].Medicine, 2017, 96(16):e6562--
[29]	Utting J C, Robins S P, Brandao-Burch A, et al.Hypoxia inhibits the growth,differentiation and bone-forming capacity of rat osteoblasts[J].Exp Cell Res, 2006, 312(10):1693-1702
[30]	董家辰，宋忠臣，束蓉，等.低氧对牙周膜成纤维细胞增殖和成骨分化的影响[J].上海口腔医学, 2014, 23(4):397-401
[31]	Qi X, Bie M, Jiang R, et al.Hif-1α regulates osteoclastogenesis and alveolar bone resorption in periodontitis via angptl4[J].Arch Oral Biol, 2023, 153(-):105736--
[32]	Zhou X, Li Y.Atlas of oral microbiology: from healthy microflora to disease[M]. Second edition. Singapore: Springer, 2020. 145-210.
[33]	Kenney E B, Ash M.Oxidation reduction potential of developing plaque,periodontal pockets and gingival sulci[J].J Periodontol, 1969, 40(11):630--
[34]	黄镜静，武曦，张纲，等.模拟高原低氧环境对兔龈下菌斑影响的实验研究[J].牙体牙髓牙周病学杂志, 2011, 21(11):623-626
[35]	Diaz P I, Rogers A H.The effect of oxygen on the growth and physiology of porphyromonas gingivalis[J].Oral Microbiol Immunol, 2004, 19(2):88-94
[36]	Lu Z, Imlay J A.When anaerobes encounter oxygen: mechanisms of oxygen toxicity,tolerance and defence[J].Nat Rev Microbiol, 2021, 19(12):774-785
[37]	Chen T, Zhou Y, Liu J, et al.Biological effects of hyperbaric oxygen on human severe periodontitis[J].Undersea Hyperb Med, 2002, 29(3):159-166
[38]	Nogueira-Filho G R, Rosa B T, David-Neto J R.Effects of hyperbaric oxygen therapy on the treatment of severe cases of periodontitis[J].Undersea Hyperbar M, 2010, 37(2):107-114
[39]	Heck T, Lohana D, Mallela D, et al.Hyperbaric oxygen therapy as an adjunct treatment of periodontitis,mronj,and onj: a systematic literature review[J].Clin Oral Invest, 2024, 28(1):77--
[40]	Asammakhi N, Darabi M A, Kehr N S, et al.Advances in controlled oxygen generating biomaterials for tissue engineering and regenerative therapy[J].Biomacromolecules, 2020, 21(1):56-72
[41]	Chen H, Cheng Y, Tian J, et al.Dissolved oxygen from microalgae-gel patch promotes chronic wound healing in diabetes[J].Sci Adv, 2020, 6(20):e-a
[42]	Guan Y, Niu H, Liu Z, et al.Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation[J].Sci Adv, 2021, 7(35):e-a
[43]	Accolla R P, Liang J, Lansberry T R, et al.Engineering modular,oxygen-generating microbeads for the in situ mitigation of cellular hypoxia[J].Adv Healthc Mater, 2023, 12(19):e2300239--
[44]	刘群峰.氧气控制释放型生物材料研究进展[J].材料研究与应用, 2021, 15(05):572-582
[45]	Sun X, Sun J, Sun Y, et al.Oxygen self-sufficient nanoplatform for enhanced and selective antibacterial photodynamic therapy against anaerobe-induced periodontal disease[J].Adv Funct Mater, 2021, 31(20):2101040--
[46]	Tan X, Liu S, Hu X, et al.Near-infrared-enhanced dual enzyme-mimicking ag-tio2-x@alginate microspheres with antibactericidal and oxygeneration abilities to treat periodontitis[J].Acs Appl Mater Inter, 2022, 15(1):391-406
[47]	Liu X, Ramsey M M, Chen X, et al.Real-time mapping of a hydrogen peroxide concentration profile across a polymicrobial bacterial biofilm using scanning electrochemical microscopy[J].P Natl Acad Sci Usa, 2011, 108(7):2668-2673
[48]	Mueller-Heupt L K, Wiesmann-Imilowski N, Schroeder S, et al.Oxygen-releasing hyaluronic acid-based dispersion with controlled oxygen delivery for enhanced periodontal tissue engineering[J].Int J Mol Sci, 2023, 24(6):5936--
[49]	赵斌.自产氧海藻酸钠复合水凝胶促进骨再生及治疗牙周炎的研究[D]. 吉林大学, 2021.
[50]	Dos Santos D M, Dias L M, Surur A K, et al.Electrospun composite bead-on-string nanofibers containing cao2 nanoparticles and mno2 nanosheets as oxygen-release systems for biomedical applications[J].ACS Appl Nano Mater., 2022, 5(10):14425-14436
[51]	王丹阳.负载益生菌的释氧水凝胶微球用于牙周炎的协同治疗[D]. 青岛大学, 2023.
[52]	Ming L, Qu Y, Wang Z, et al.Small extracellular vesicles laden oxygen-releasing thermosensitive hydrogel for enhanced antibacterial therapy against anaerobe-induced periodontitis alveolar bone defect[J].Acs Biomater Sci Eng, 2024, 10(2):932-945
[53]	Ozcelik H, Batool F, Corre M, et al.Characterization of a hyaluronic acid-based hydrogel containing an extracellular oxygen carrier (m101) for periodontitis treatment: an in vitro study[J].Int J Pharmaceut, 2021, 605(-):120810--
[54]	Zal F, Green B N, Lallier F H, et al.Quaternary structure of the extracellular haemoglobin of the lugworm arenicola marina - a multi-angle-laser-light-scattering and electrospray-ionisation-mass-spectrometry analysis[J].Eur. J. Biochem, 1997, 243(1-2):85-92
[55]	Batool F, Petit C, Stutz C, et al.M101,a therapeutic oxygen carrier derived from arenicola marina,decreased porphyromonas gingivalis- induced hypoxia and improved periodontal healing[J].J Periodontol, 2022, 93(11):1712-1724

Hypoxia and periodontitis: Occurrence, progression, and novel treatment strategies

Knowledge

Abstract

Cite this article

share this article

References 55

Related Articles 10

Recommended Articles

Metrics

Comments

[1]	. Hydrogen sulfide improves orthodontic force-induced osteogenesis of periodontal tissue in inflammatory microenvironment [J]. Oral Biomedicine, 2022, 13(1): 20-25.
[2]	. Effects of Non-surgical Periodontal Treatment on Nitric Oxide and Blood Pressure [J]. Oral Biomedicine, 2022, 13(1): 30-34.
[3]	. The senescence of dental stem cells and its related mechanisms [J]. Oral Biomedicine, 2021, 12(4): 277-280.
[4]	. The possible role of the microbe-gut-brain axis in the relationship between chronic periodontitis and Alzheimer′s disease [J]. Oral Biomedicine, 2021, 12(1): 62-65.
[5]	. Preparation and biocompatibility of polycaprolactone/type I collagen/fluoroapatite composite scaffold [J]. , 2019, 10(1): 12-16.
[6]	. Effect of Porphyromonas gingivalis lipopolysaccharide on the of EphA4 gene in ST-2 Cells [J]. , 2017, 8(1): 25-27.
[7]	. The application of periodontal ligament derived cell sheet in the periodontal regeneration. [J]. , 2016, 7(2): 104-107.
[8]	. Application of acellular dermal matrix in mucogingiva surgery and its recent research progress [J]. , 2015, 6(1): 45-49.
[9]	. Chronic periodontitis is Risk factor that influence human health [J]. , 2013, 4(2): 103-106.
[10]	. Comparative study of the Phagocytosis of Actinobacillus actinomycetemcomitans(Aa) by monocytes/macrophages of different tissues [J]. , 2012, 3(4): 169-172.