脱钙骨基质的骨修复功能及其在口腔临床医学中的应用前景

›› 2012, Vol. 3 ›› Issue (2): 94-97.

脱钙骨基质的骨修复功能及其在口腔临床医学中的应用前景

马艳红¹,刘茜¹,梅予锋²

1. 南京医科大学口腔医学研究所
2. 南京医科大学

收稿日期:2012-02-13 修回日期:2012-06-01 出版日期:2012-06-25 发布日期:2012-06-26
通讯作者: 梅予锋 E-mail:yf88mei@yahoo.com.cn

The bone repair function of demineralized bone matrix and its application prospects in the oral clinical medicine.

Received:2012-02-13 Revised:2012-06-01 Online:2012-06-25 Published:2012-06-26

摘要/Abstract

摘要： 摘要：脱钙骨基质（Demineralized bone matrix,DBM）是同种异体或异种骨经过脱钙、脱脂、去蛋白处理得到的产物，主要成分包括胶原和骨形态发生蛋白（Bone morphogenetic proteins,BMPs），具有良好的生物相容性和满意的三维空间结构，并且能够诱导未分化的间充质细胞分化为成骨和成软骨细胞，在骨、软骨形成过程中发挥重要作用。目前，应用DBM进行骨缺损的修复治疗显示了良好的临床效果，本文针对DBM在骨缺损修复中的作用机制及其在口腔颌面部的应用做一综述，并展望DBM在牙体牙髓修复中的应用。

Abstract: Abstract：Demineralized bone matrix (DBM) is a product which is created through demineralized, degreased and deproteinized of allograft or xenograft. DBM is mainly comprised of collagen and bone morphogenetic proteins (BMPs). It has satisfied biocompatibility and excellent three-dimensional space and can stimulate local undifferentiated mesenchymal cells to transform into osteoblasts or Chondroblasts, this is important for promoting the formation of bone and cartilage. This material has been used in clinical for the treatment of bone defects and shows good results. The purpose of this paper is to review the mechanism of the DBM in repairing bone defects, oral maxillofacial applications and to prospect the feasibility applications of DBM in dental pulp repair.

中图分类号:

R687.3

马艳红刘茜梅予锋. 脱钙骨基质的骨修复功能及其在口腔临床医学中的应用前景[J]. , 2012, 3(2): 94-97.

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