›› 2012, Vol. 3 ›› Issue (3): 151-154.

• 综述 • 上一篇    下一篇

放化疗性口腔黏膜炎模型建立及防治现状

王怡娟,王松灵   

  1. 首都医科大学
  • 收稿日期:2012-06-07 修回日期:2012-07-16 出版日期:2012-09-25 发布日期:2012-10-08
  • 通讯作者: 王松灵 E-mail:slwang@ccmu.edu.cn

Animal models and treatments of radiochemotherapy-induced oral mucositis

  • Received:2012-06-07 Revised:2012-07-16 Online:2012-09-25 Published:2012-10-08

摘要: 与癌症治疗相关的口腔黏膜炎被认为是最重要的放化疗急性并发症。一般来说,头颈部癌症放疗或放化疗引起的口腔黏膜炎发病率较高,也较为严重;单纯化疗引起的口腔黏膜炎发病率较低,程度较轻。严重的口腔黏膜炎造成病人疼痛、吞咽困难、继发感染、营养障碍,影响癌症的治疗,给病人造成了极大的痛苦。本文对国内外口腔黏膜炎动物模型建立情况和新近的各种防治方法进行综述。

Abstract: Oral mucositis is a common side effect of cancer therapies, particularly radiation therapy for head and neck cancer and various forms of chemotherapy. Radiation-induced oral mucositis has got a higher incidence and much severer than the one caused by chemotherapy. In addition to pain, dysphagia, secondary infection and dystrophia, severe oral mucositis limits cancer treatment. This article summarized the existing international and national situation of animal model for oral mucositis and its ways of prevention.

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