›› 2012, Vol. 3 ›› Issue (4): 197-200.

• 论著 • 上一篇    下一篇

Kimura病的临床病理观察

肖璇1,王聪1,徐祎2   

  1. 1. 江苏省人民医院
    2. 南京医科大学第一附属医院
  • 收稿日期:2012-09-10 修回日期:2012-11-21 出版日期:2012-12-25 发布日期:2013-01-10
  • 通讯作者: 肖璇 E-mail:xiaoxuan_1983@163.com

The clinicopathologic observation of Kimura disease

  • Received:2012-09-10 Revised:2012-11-21 Online:2012-12-25 Published:2013-01-10

摘要: [摘要]目的 探讨Kimura病(Kimura’ disease,KD)的临床病理特点,提高对该病的认识。方法 分析和观察7例KD的临床资料、病理组织学表现及免疫表型。结果 7例KD患者均为男性,发病年龄21-73岁,主要表现为头颈部皮下或大唾液腺的无痛性肿块,组织学上以淋巴组织增生为主,可见淋巴滤泡形成,生发中心扩大,滤泡间见血管增生,大量嗜酸性粒细胞浸润。免疫组织化学显示KD中的淋巴滤泡表达B细胞抗原,滤泡间的淋巴细胞多表达T细胞标记。结论 KD是一种少见的淋巴组织增生性疾病,需与部分富含淋巴组织的肿瘤鉴别,组织病理学对其诊断具有重要意义。

Abstract: 【Abstract】 Objective To improve the knowledge of the clinicopathologic features of Kimura disease(KD). Methods seven cases of Kimura disease were evaluated by light microscopy and immunohistochemistry. Results All the 7 cases were male, the age of onset were from 21 to 73 years. The typical clinical presentation was characterizde by painless subcutaeous and major salivary glands in the head and neck.The pathological characterisitics of KD were lymphoid tissue hyperplasia with prominent lymphoid follicles,enlargement of germinal center, conspicuous eosinophils infiltration and capillary proliferation. Immunohistochemical study in KD revealed B cells in the lymphoid follicles and mostly T cells in the interfollicular regions. Conclusions KD is an uncommon lymphoid tissue hyperplasia. It should be differentiated from tumor abundant with lymph tissue. The histopathologic diagnosis of KD is important.