叉头框蛋白O转录因子调节骨平衡

›› 2016, Vol. 7 ›› Issue (1): 42-45.

叉头框蛋白O转录因子调节骨平衡

谭学莲¹,黄定明²,张岚¹

1. 四川大学华西口腔医院牙体牙髓科，口腔疾病研究国家重点实验室
2. 四川大学华西口腔医院牙体牙髓科

收稿日期:2016-01-26 修回日期:2016-03-14 出版日期:2016-03-25 发布日期:2016-04-06
通讯作者: 张岚 E-mail:zlnancy914@sina.com
基金资助:
根尖周炎中Dickkopf-1（Dkk-1）诱发骨组织去耦联的机制;IKK-NF-κB与Wnt/β-catenin信号通路在咬合创伤调控根尖周骨代谢中的作用机制

The O class of Forkhead transcriptional factor modulates bone homeostasis

Received:2016-01-26 Revised:2016-03-14 Online:2016-03-25 Published:2016-04-06

摘要/Abstract

摘要： 叉头框蛋白O(the O class of Forkhead, FoxO）转录因子属于叉头框蛋白家族的一个亚类，可在慢性炎症反应中参与骨耦联、溶骨性病损的形成以及骨代谢平衡的体内调控。慢性根尖周炎是发生在牙齿根尖周组织的慢性炎症性疾病，可引起根尖周骨质丧失，研究FoxO转录因子在骨代谢中的作用和相关机制，对于为慢性根尖周炎寻求新的治疗途径具有重要意义。本文就FoxO转录因子对细胞增殖与凋亡、成骨分化的调节作用，以及与炎症、炎症因子、氧化应激间的关系作一综述。

Abstract: The O class of Forkhead (FoxO) transcriptional factor belongs to the Forkhead proteins family, regulating bone coupling, development of osteolytic lesions and bone homeostasis in chronic inflammations. Chronic apical periodontitis is a kind of chronic inflammatory disease occurring in the periapical tissues, leading to periapical bone loss. So insights of how FoxO transcription factors act on bone metabolism maybe contribute to seek new treatment for chronic apical periodontitis. In this review, the role of FoxO transcription factors on cell proliferation, apoptosis and osteogenetic differentiation, as well as the relationship between FoxO and inflammation, inflammation factors, oxidative stress are presented .

谭学莲黄定明张岚. 叉头框蛋白O转录因子调节骨平衡[J]. , 2016, 7(1): 42-45.

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