肿瘤相关巨噬细胞和MMP-2在成釉细胞瘤中的表达及意义

›› 2016, Vol. 7 ›› Issue (2): 76-78.

肿瘤相关巨噬细胞和MMP-2在成釉细胞瘤中的表达及意义

孙福星,范亚伟

山西医科大学

收稿日期:2016-03-21 修回日期:2016-05-24 出版日期:2016-06-25 发布日期:2016-06-22
通讯作者: 范亚伟 E-mail:yaweifan@hotmail.com

Expression and clinical significance of tumor-associated macrophages and matrix metalloproteinase-2 in ameloblastomas

Received:2016-03-21 Revised:2016-05-24 Online:2016-06-25 Published:2016-06-22

摘要/Abstract

摘要： 目的：探讨肿瘤相关巨噬细胞（TAMs）和基质金属蛋白酶-2（MMP-2）在人成釉细胞瘤（ABs）中的表达及意义。方法：采用免疫组化通用二步法，分别检测43例ABs和10例正常口腔黏膜中CD68标记的巨噬细胞数目及MMP-2的表达情况。结果：TAMs和MMP-2在ABs中的表达均高于正常黏膜，差异有统计学意义（P<0.01）。在ABs中，TAMs主要表达于肿瘤间质，MMP-2主要表达于肿瘤实质，MMP-2表达强度随着TAMs计数增加而增加，二者呈正相关关系（r=0.331，P<0.05）。结论：TAMs和MMP-2在ABs中的共同表达可能在其发生发展中发挥重要作用。

Abstract: Objective：To investigate the and clinical significance of tumor-associated macrophages(TAMs) and matrix metalloproteinase-2(MMP-2) in ameloblastomas（ABs）. Methods： The of TAMs(CD68) and MMP-2 was examined in 43 ABs and 10 normal oral mucosa by universal two-step immunohistochemical technique. Results：Expression of TAMs and MMP-2 were significantly higher in ABs compared with normal oral mucosa(P<0.01). TAMs was mainly expressed within the stroma and MMP-2 was mainly expressed within the islands of ABs. There was a positive correlation between MMP-2 score and TAMs count in ABs(r=0.331, P<0.05). Conclusions：The common of TAMs and MMP-2 may play an important role in the development of ABs.

孙福星范亚伟. 肿瘤相关巨噬细胞和MMP-2在成釉细胞瘤中的表达及意义[J]. , 2016, 7(2): 76-78.