CD3+、CD8+ T细胞与口腔扁平苔藓糜烂的关系

›› 2017, Vol. 8 ›› Issue (4): 195-198.

CD3+、CD8+ T细胞与口腔扁平苔藓糜烂的关系

朱丽芳¹,余淼²,潘璐³,郑阳玉²,张玮⁴,刘来奎⁵,徐艳⁶

1. 苏州大学附属第一医院
2. 南京医科大学附属口腔医院
3. 南京医科大学附属口腔医院基础教研室
4. 江苏省口腔医院口腔颌面外科
5. 南京医科大学口腔研究所
6. 南京医科大学口腔医学院

收稿日期:2017-10-27 修回日期:2017-11-09 出版日期:2017-12-25 发布日期:2017-12-26
通讯作者: 徐艳 E-mail:xuyan@njmu.edu.cn
基金资助:
A20基于细胞自噬调控牙周炎骨破坏的相关机制研究;CAFs重塑基质微环境激活SDF1/CXCR4信号调控巨噬细胞分化与口腔癌侵袭转移机制研究;肿瘤相关巨噬细胞分泌TNF-α调控Snail促口腔癌侵袭转移的研究

Relationship between CD3+ T cell and CD8+ T cell infiltration and erosion in oral lichen planus

Received:2017-10-27 Revised:2017-11-09 Online:2017-12-25 Published:2017-12-26

摘要/Abstract

摘要： 目的：探讨CD3+、CD8+ T细胞与口腔扁平苔藓（OLP）临床病理特征的相关性。方法：选取79例OLP患者作为研究对象，10例正常口腔黏膜组织作为对照，采用免疫组化半定量法检测CD3+、CD8+ T细胞在组织中的表达，统计分析CD3+、CD8+ T细胞浸润与OLP临床病理特征的关系。结果：CD3+、CD8+ T细胞在OLP中阳性表达，在正常口腔黏膜组织中呈阴性表达。CD3+ T细胞浸润与患者性别、年龄、部位无明显相关性，但是与OLP发生糜烂密切相关（P＜0.05）；CD8+ T细胞浸润与OLP患者性别、年龄、部位及有无糜烂均无明显相关性。结论：CD3+ T细胞浸润对OLP发生糜烂有影响。

Abstract: Objective：To investigate the relationship between CD3+ T cells and CD8+ T cells and clinicopathological features of oral lichen planus (OLP). Methods：We detected the expression of CD3 and CD8 in 79 cases of OLP and 10 cases of normal oral mucosa by using semi-quantitative immunohistochemistry. The relationship between the expression of these T cells and clinicopathological parameters were analyzed statistically. Results：The expression of CD3 and CD8 were positive in OLP and negative in normal oral mucosa. The infiltration of CD3+ T cells had no relationship with gender, age or the location of OLP, but it was closely related to the development of erosion in OLP, which was statistically significant (P＜0.05). However, there was no relationship between the CD8+ T cells and gender, age, location or erosion of OLP. Conclusions：The infiltration of CD3+ T cells affected the incidence of erosion in OLP.

朱丽芳余淼潘璐郑阳玉张玮刘来奎徐艳. CD3+、CD8+ T细胞与口腔扁平苔藓糜烂的关系[J]. , 2017, 8(4): 195-198.

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