低密度脂蛋白受体相关蛋白与骨骼发育及骨相关疾病

摘要/Abstract

摘要： 低密度脂蛋白受体（LDLR）家族部分成员可作为WNT/β-catenin信号通路的辅助性受体，在骨骼发育及骨稳态维持中起到重要作用。本文总结LDLR家族中4种低密度脂蛋白受体相关蛋白（LRP）对骨发育的影响，探讨LRP功能缺失引起的骨质疏松、骨硬化、关节炎、牙齿及肢端发育缺陷等疾病最新研究动态及治疗手段，以期为LRP相关骨骼疾病的诊断和治疗提供参考。

关键词: 低密度脂蛋白受体, 骨稳态, WNT/β-catenin信号通路, 骨相关疾病

Key words: LRPs, Bone homeostasis, WNT/β-catenin, Skeletal disease

卢淑娴吕赵劼王志浩寇瑶田静. 低密度脂蛋白受体相关蛋白与骨骼发育及骨相关疾病[J]. 口腔生物医学, 2020, 11(3): 191-196.

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低密度脂蛋白受体相关蛋白与骨骼发育及骨相关疾病

Low-density lipoprotein receptor-related proteins in skeletal development and disease

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