长链非编码RNA在干细胞成骨分化中作用机制的研究进展

摘要/Abstract

摘要： 在骨相关疾病治疗和骨组织工程中，干细胞作为成骨细胞的主要来源发挥着重要作用。长链非编码RNA（long non-coding RNA，lncRNA）可调控细胞周期、增殖代谢及谱系分化。随着高通量测序等研究技术的发展，lncRNA被发现可广泛参与干细胞的成骨调节。miRNA海绵作用是lncRNA调控成骨最经典的机制，近年来有关RNA结合蛋白、DNA甲基化等作用机制的研究愈加深入。此外，众多经典成骨信号通路，如Wnt/β-catenin、TGF-β/Smads等在lncRNA调控成骨中的作用也逐渐被验证，两者共同展现了lncRNA在骨代谢和骨再生治疗中的潜在靶标性。本文将就lncRNA在干细胞成骨分化中的作用机制及相关信号通路做一综述。

关键词: 长链非编码RNA, 骨髓间充质干细胞, 牙周膜干细胞, 成骨分化, 骨再生

Abstract: 无

Key words: long non-coding RNA, bone marrow mesenchymal stem cell, periodontal ligament stem cell, osteogenesis, bone regeneration

胡琮佼孙瑶. 长链非编码RNA在干细胞成骨分化中作用机制的研究进展[J]. 口腔生物医学, 2021, 12(3): 205-210.

Cong-Jiao HU. Research progress on the mechanism of IncRNA in osteogenic differentiation of stem cells[J]. Oral Biomedicine, 2021, 12(3): 205-210.

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