口腔生物医学 ›› 2022, Vol. 13 ›› Issue (2): 116-119.

• 综述 • 上一篇    下一篇

甘露糖的生物学作用研究进展

陈颖怡1,杜鹃2,罗振华2,郭力嘉2,徐骏疾2,刘怡2   

  1. 1. 首都医科大学附属北京口腔医院研究所
    2. 首都医科大学附属北京口腔医院
  • 收稿日期:2022-03-08 修回日期:2022-04-12 出版日期:2022-06-25 发布日期:2022-07-07
  • 通讯作者: 刘怡 E-mail:lililiuyi@163.com
  • 基金资助:
    国家自然科学基金重大项目;首都医科大学附属北京口腔院创新团队建设项目

Progress of Sdudies on The Biological Effects of D-Mannose

  • Received:2022-03-08 Revised:2022-04-12 Online:2022-06-25 Published:2022-07-07

摘要: 甘露糖是一种广泛分布于体液和组织中的单糖,特别是在神经、皮肤、睾丸、视网膜、肝脏和肠道中,具有多重调节功能。甘露糖不仅能够抑制病原微生物定植,预防尿路感染,能够抑制肿瘤细胞糖代谢,发挥抗肿瘤功能,还能够通过调节宿主免疫细胞及肠道菌群来调节免疫反应。本文对甘露糖的生物学作用和临床应用潜力进行综述。

关键词: 甘露糖, 免疫调节, 抗细菌, 肿瘤

Abstract: D-Mannose is a kind of monosaccharide that widely distribute in body fluids and tissues, especially in nerves, skin, testis, retina, liver and intestines. It could display multiple functions. D-Mannose can inhibit the colonization of pathogenic microorganisms and prevent urinary tract infection. D-Mannose could also play an anti-tumor function by inhibiting glucose metabolism of tumor cells. In addition, D-Mannose can regulate the immune response by regulating host immune cells and intestinal flora. In recent years, the biological effects of D-Mannose have been more and more deeply understood by scholars. This paper reviewed the latest progress of medical research on mannose and pointed out the potential of mannose in clinical application.

Key words: D-Mannose, Neoplasms