槲皮素对头颈部肿瘤治疗作用机制的研究进展

摘要/Abstract

摘要： 头颈部肿瘤是一种常见的恶性肿瘤，其死亡率高，预后较差。槲皮素是黄酮类化合物之一，普遍分布在水果、蔬菜和药材中，具有多重生物学活性和药理作用。据报道其对包括头颈部肿瘤在内的各种癌症具有抗肿瘤作用，可通过抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、抑制肿瘤侵袭和转移、抑制肿瘤新生血管生成、逆转化疗耐药和化疗增敏等多种方式有效地防治头颈部肿瘤。本文旨在对近年来国内外有关槲皮素治疗头颈部肿瘤的作用机制进行综述。

关键词: 槲皮素, 头颈部肿瘤, 作用机制

Abstract: Head and neck cancer is a common malignancy with a high mortality rate and poor prognosis. Quercetin, a flavonoid, is commonly found in many fruits, vegetables, and medicinal herbs and has a variety of biological and pharmacological effects. It has been shown to have anti-tumor effects on a variety of cancers, including head and neck cancer, and can effectively prevent and treat head and neck cancer by inhibiting tumor cell growth, inducing tumor cell apoptosis, inhibiting tumor invasion and metastasis, inhibiting angiogenesis, reversing drug resistance, and enhancing chemotherapy sensitization in a variety of ways. This paper aims to review the mechanism of action of quercetin in treating head and neck cancer in recent years.

Key words: quercetin, head and neck cancer, mechanism of action

中图分类号:

R780.1

邹子川周霖陈寅瑜孟箭. 槲皮素对头颈部肿瘤治疗作用机制的研究进展[J]. 口腔生物医学, 2023, (3): 206-210.

参考文献

[1] Chow L. Head and Neck Cancer[J]. N. Engl. J. Med.,2020,382(1);60-72.
[2] Parmar A, Macluskey M, Mc G N, et al. Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy[J]. Cochrane Database Syst Rev.,2021,12(12);D6386.
[3] Di Petrillo A, Orru G, Fais A, et al. Quercetin and its derivates as antiviral potentials: A comprehensive review[J]. Phytother. Res.,2022,36(1);266-278.
[4] Deepika, Maurya P K. Health Benefits of Quercetin in Age-Related Diseases[J]. Molecules,2022,27(8).
[5] Nguyen T, Bhattacharya D. Antimicrobial Activity of Quercetin: An Approach to Its Mechanistic Principle[J]. Molecules,2022,27(8).
[6] Samadi F, Kahrizi M S, Heydari F, et al. Quercetin and Osteoarthritis: A Mechanistic Review on the Present Documents[J]. Pharmacology,2022,107(9-10);464-471.
[7] Papakyriakopoulou P, Velidakis N, Khattab E, et al. Potential Pharmaceutical Applications of Quercetin in Cardiovascular Diseases[J]. Pharmaceuticals,2022,15(8).
[8] He C, Lu X, Li J, et al. The effect of quercetin on cervical cancer cells as determined by inducing tumor endoplasmic reticulum stress and apoptosis and its mechanism of action[J]. Am. J. Transl. Res.,2021,13(5);5240-5247.
[9] Khorsandi L, Orazizadeh M, Niazvand F, et al. Quercetin induces apoptosis and necroptosis in MCF-7 breast cancer cells[J]. Bratisl. Med. J.,2017,118(2);123-128.
[10] Eastham L L, Howard C M, Balachandran P, et al. Eating Green: Shining Light on the Use of Dietary Phytochemicals as a Modern Approach in the Prevention and Treatment of Head and Neck Cancers[J]. Curr. Top. Med. Chem.,2018,18(3);182-191.
[11] Sun Y, Liu Y, Ma X, et al. The Influence of Cell Cycle Regulation on Chemotherapy[J]. Int. J. Mol. Sci.,2021,22(13).
[12] Kim S R, Lee E Y, Kim D J, et al. Quercetin Inhibits Cell Survival and Metastatic Ability via the EMT-mediated Pathway in Oral Squamous Cell Carcinoma[J]. Molecules,2020,25(3).
[13] Yuan Z, Wang H, Hu Z, et al. Quercetin inhibits proliferation and drug resistance in KB/VCR oral cancer cells and enhances its sensitivity to vincristine[J]. Nutr. Cancer,2015,67(1);126-136.
[14] Chen S F, Nien S, Wu C H, et al. Reappraisal of the anticancer efficacy of quercetin in oral cancer cells[J]. J. Chin. Med. Assoc.,2013,76(3);146-152.
[15] Son H K, Kim D. Quercetin Induces Cell Cycle Arrest and Apoptosis in YD10B and YD38 Oral Squamous Cell Carcinoma Cells[J]. Asian Pac J Cancer Prev,2023,24(1);283-289.
[16] 陈创茂，宋静琴，陈志俊，等. 槲皮素通过调控p21/cip1和p27/kip1蛋白的稳定性抑制口腔鳞状细胞癌细胞增殖[J]. 现代肿瘤医学,2021,29(06);924-929.
[17] Huang C Y, Chan C Y, Chou I T, et al. Quercetin induces growth arrest through activation of FOXO1 transcription factor in EGFR-overexpressing oral cancer cells[J]. J. Nutr. Biochem.,2013,24(9);1596-1603.
[18] Pistritto G, Trisciuoglio D, Ceci C, et al. Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies[J]. Aging (Albany NY),2016,8(4);603-619.
[19] Carneiro B A, El-Deiry W S. Targeting apoptosis in cancer therapy[J]. Nat. Rev. Clin. Oncol.,2020,17(7);395-417.
[20] Ma Y S, Yao C N, Liu H C, et al. Quercetin induced apoptosis of human oral cancer SAS cells through mitochondria and endoplasmic reticulum mediated signaling pathways[J]. Oncol. Lett.,2018,15(6);9663-9672.
[21] Huang C F, Liu S H, Ho T J, et al. Quercetin induces tongue squamous cell carcinoma cell apoptosis via the JNK activation-regulated ERK/GSK-3alpha/beta-mediated mitochondria-dependent apoptotic signaling pathway[J]. Oncol. Lett.,2022,23(3);78.
[22] Georgaki M, Theofilou V I, Pettas E, et al. Understanding the complex pathogenesis of oral cancer: A comprehensive review[J]. Oral Surg. Oral Med. Oral Pathol. Oral Radiol.,2021,132(5);566-579.
[23] Chen L, Xia J S, Wu J H, et al. Quercetin suppresses cell survival and invasion in oral squamous cell carcinoma via the miR-1254/CD36 cascade in vitro[J]. Hum. Exp. Toxicol.,2021,40(9);1413-1421.
[24] Zhang C, Hao Y, Sun Y, et al. Quercetin suppresses the tumorigenesis of oral squamous cell carcinoma by regulating microRNA-22/WNT1/beta-catenin axis[J]. J. Pharmacol. Sci.,2019,140(2);128-136.
[25] Wang Y, Chen X, Li J, et al. Quercetin Antagonizes Esophagus Cancer by Modulating miR-1-3p/TAGLN2 Pathway-Dependent Growth and Metastasis[J]. Nutr. Cancer,2022,74(5);1872-1881.
[26] Pfeffer C M, Singh A. Apoptosis: A Target for Anticancer Therapy[J]. Int. J. Mol. Sci.,2018,19(2).
[27] Hu X, Xia K, Xiong H, et al. G3BP1 may serve as a potential biomarker of proliferation, apoptosis, and prognosis in oral squamous cell carcinoma[J]. J. Oral Pathol. Med.,2021,50(10);995-1004.
[28] Shi J, Ye J, Fei H, et al. YWHAZ promotes ovarian cancer metastasis by modulating glycolysis[J]. Oncol. Rep.,2019,41(2);1101-1112.
[29] Hu M, Song H Y, Chen L. Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma[J]. Toxicol. Mech. Methods,2023,33(2);141-150.
[30] Banyard J, Bielenberg D R. The role of EMT and MET in cancer dissemination[J]. Connect. Tissue Res.,2015,56(5);403-413.
[31] Chang W W, Hu F W, Yu C C, et al. Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer[J]. Head Neck-J. Sci. Spec. Head Neck,2013,35(3);413-419.
[32] Chan C Y, Lien C H, Lee M F, et al. Quercetin suppresses cellular migration and invasion in human head and neck squamous cell carcinoma (HNSCC)[J]. BioMedicine-Taiwan,2016,6(3);15.
[33] 肖兰飞，高继萍，闫晓如，等. 槲皮素对口腔癌Tca-8113细胞增殖、迁移和侵袭的影响及PI3K/AKT信号通路的调控作用[J]. 中国比较医学杂志,2021,31(06);30-34.
[34] Yu H, Lin L, Zhang Z, et al. Targeting NF-kappaB pathway for the therapy of diseases: mechanism and clinical study[J]. Signal Transduct. Target. Ther.,2020,5(1);209.
[35] Lai W W, Hsu S C, Chueh F S, et al. Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-kappaB and matrix metalloproteinase-2/-9 signaling pathways[J]. Anticancer Res.,2013,33(5);1941-1950.
[36] Tecalco-Cruz A C. Molecular Pathways of Interferon-Stimulated Gene 15: Implications in Cancer[J]. Curr. Protein Pept. Sci.,2021,22(1);19-28.
[37] 张齐梅，周骢，伍宝琴，等. 槲皮素对口腔鳞状细胞癌ISG15表达及细胞迁移侵袭影响[J]. 泸州医学院学报,2016,39(03);242-244.
[38] Lugano R, Ramachandran M, Dimberg A. Tumor angiogenesis: causes, consequences, challenges and opportunities[J]. Cell. Mol. Life Sci.,2020,77(9);1745-1770.
[39] Liu Y, Li C L, Xu Q Q, et al. Quercetin inhibits invasion and angiogenesis of esophageal cancer cells[J]. Pathol. Res. Pract.,2021,222;153455.
[40] Wu Q, Deng S, Li L, et al. Biodegradable polymeric micelle-encapsulated quercetin suppresses tumor growth and metastasis in both transgenic zebrafish and mouse models[J]. Nanoscale,2013,5(24);12480-12493.
[41] Qi X, Gao C, Yin C, et al. Development of quercetin-loaded PVCL-PVA-PEG micelles and application in inhibiting tumor angiogenesis through the PI3K/Akt/VEGF pathway[J]. Toxicol. Appl. Pharmacol.,2022,437;115889.
[42] Maurya A K, Vinayak M. Quercetin Attenuates Cell Survival, Inflammation, and Angiogenesis via Modulation of AKT Signaling in Murine T-Cell Lymphoma[J]. Nutr. Cancer,2017,69(3);470-480.
[43] Esteghlal S, Mokhtari M J, Beyzaei Z. Quercetin Can Inhibit Angiogenesis via the Down Regulation of MALAT1 and MIAT LncRNAs in Human Umbilical Vein Endothelial Cells[J]. Int. J. Preventive Med.,2021,12;59.
[44] Haider T, Pandey V, Banjare N, et al. Drug resistance in cancer: mechanisms and tackling strategies[J]. Pharmacol. Rep.,2020,72(5);1125-1151.
[45] Bukowski K, Kciuk M, Kontek R. Mechanisms of Multidrug Resistance in Cancer Chemotherapy[J]. Int. J. Mol. Sci.,2020,21(9).
[46] Li X, Guo S, Xiong X K, et al. Combination of quercetin and cisplatin enhances apoptosis in OSCC cells by downregulating xIAP through the NF-kappaB pathway[J]. J. Cancer,2019,10(19);4509-4521.
[47] Li T, Li Y. Quercetin acts as a novel anti-cancer drug to suppress cancer aggressiveness and cisplatin-resistance in nasopharyngeal carcinoma (NPC) through regulating the yes-associated protein/Hippo signaling pathway[J]. Immunobiology,2023,228(2);152324.
[48] Pham T, Stempel S, Shields M A, et al. Quercetin Enhances the Anti-Tumor Effects of BET Inhibitors by Suppressing hnRNPA1[J]. Int. J. Mol. Sci.,2019,20(17).
[49] Chan S T, Chuang C H, Lin Y C, et al. Quercetin enhances the antitumor effect of trichostatin A and suppresses muscle wasting in tumor-bearing mice[J]. Food Funct.,2018,9(2);871-879.
[50] Saputra O A, Lestari W A, Kurniansyah V, et al. Organically surface engineered mesoporous silica nanoparticles control the release of quercetin by pH stimuli[J]. Sci Rep,2022,12(1);20661.