牙周膜干细胞在外泌体介导的牙周组织再生中的双重角色

摘要/Abstract

摘要： 牙周膜干细胞（PDLSC）作为具有多向分化潜能的间充质干细胞，在外泌体介导的牙周组织再生中发挥着重要作用。PDLSC通过分泌外泌体促进骨形成、血管新生及抗炎等过程，通过接受外源性外泌体调控其再生行为。本文对PDLSC在外泌体介导的牙周组织再生中的研究进展进行综述，并展望了其未来应用。

关键词: 牙周炎, 牙周膜干细胞, 外泌体, 牙周组织再生

Abstract: Periodontal ligament stem cell（PDLSC）, as a mesenchymal stem cell with multipotent differentiation capabilities, plays a critical role in periodontal tissue regeneration. Periodontal ligament stem cells promote bone formation, angiogenesis, and anti-inflammatory processes by secreting exosomes, and regulate their regenerative behavior through the uptake of exogenous exosomes. This review summarizes the recent advancements in research on periodontal ligament stem cells in exosome-mediated periodontal tissue regeneration and provides insights into their future applications.

Key words: Periodontitis, Periodontal ligament stem cells, Exosome, Periodontal tissue regeneration

张承鹏顾永春. 牙周膜干细胞在外泌体介导的牙周组织再生中的双重角色[J]. 口腔生物医学, 2025, 16(3): 176-180.

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