中国汉族人群rs1229984多态性与头颈癌发病风险的关联研究

›› 2012, Vol. 3 ›› Issue (4): 173-177.

中国汉族人群rs1229984多态性与头颈癌发病风险的关联研究

袁志瑶,袁华,朱龙彪,沈铭,李俊,陈宁

南京医科大学口腔医学院

收稿日期:2012-08-02 修回日期:2012-11-21 出版日期:2012-12-25 发布日期:2013-01-10
通讯作者: 陈宁 E-mail:njcn@njmu.edu.cn

Investigation of rs1229984 polymorphisms are associated with head and neck cancer risk in a Chinese Han population

Received:2012-08-02 Revised:2012-11-21 Online:2012-12-25 Published:2013-01-10

摘要/Abstract

摘要： ［摘要］目的：研究寻找与中国汉族人群头颈癌遗传易感性相关的多态位点。方法：采用病例-对照的研究设计，运用TaqMan基因分型方法，在397例新发头颈癌患者和900例性别、年龄相匹配的对照中分析了5个多态位点的遗传变异与中国汉族人群头颈癌易感性的关系。结果：rs1229984（A>G）的遗传变异能够显著影响头颈癌的发病风险。携带rs1229984 AG/GG基因型者罹患头颈癌的风险较携带AA基因型者增加34%（调整OR=1.34，95% CI=1.05-1.71）。本研究未发现其余4个位点多态性与头颈癌之间存在显著性相关。结论：染色体4q23区域的rs1229984多态性与中国汉族人群头颈癌的易感性有关。

Abstract: ［Abstract］Objective: To investigate the single nucleotide polymorphism with significant association on the head and neck cancer (HNC) risk in a Chinese Han population．Methods：We genotyped five variants (rs1494961, rs1229984, rs1789924, rs971074 and rs4767364) in a case-control study with 397 HNC cases and 900 controls, using the TaqMan allelic discrimination assay. Results：We found that rs1229984 at 4q23 significantly increased the risk of HNC [adjusted odds ratio (OR) =1.34, 95% con?dence interval (CI) = 1.05-1.71]. By contrast，no significant association was observed between the other four single nucleotide polymorphisms (SNPs) and HNC risk．Conclusion：These findings suggest that rs1229984 at 4q23 may serve as candidate marker for HNC susceptibility in a Chinese population.

袁志瑶袁华朱龙彪沈铭李俊陈宁. 中国汉族人群rs1229984多态性与头颈癌发病风险的关联研究[J]. , 2012, 3(4): 173-177.

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