›› 2020, Vol. 11 ›› Issue (1): 1-8.
• 述评 • 下一篇
窦庚1,刘世宇1,金岩2
收稿日期:2020-02-05
修回日期:2020-03-05
出版日期:2020-03-25
发布日期:2020-04-07
通讯作者:
金岩
E-mail:yanjin@fmmu.edu.cn
Received:2020-02-05
Revised:2020-03-05
Online:2020-03-25
Published:2020-04-07
摘要： 细胞外囊泡（Extracellular Vesicles,EVs）是细胞分泌释放的微小囊泡，其中包含核酸、蛋白质等生物活性分子，在细胞间通讯和信号传导中发挥着重要的作用。研究表明，细胞外囊泡可以通过递送生物活性分子，在多种疾病中起到治疗的作用，有望成为新一代药物递送的天然载体。相较于传统纳米材料，天然EVs靶向递送具有低免疫原性、良好生物相容性、天然靶向性、长循环时间等明显优势，因而受到研究者的青睐。通过进一步组织工程手段来个性化构建EVs，提高其靶向性和目标治疗分子负载能力，为靶向分子治疗提供了一种新的治疗策略。本文将对EVs在组织工程构建策略方面的研究现状和前景作一简述。
窦庚 刘世宇 金岩. 细胞外囊泡在组织工程研究中的新应用[J]. 口腔生物医学, 2020, 11(1): 1-8.
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