炎症微环境影响牙周膜干细胞成骨分化的信号通路

摘要/Abstract

摘要： 牙周膜干细胞（PDLSC）应用于组织工程学是目前治疗牙周炎骨缺失最有前景的方法之一，然而目前体内应用PDLSC再生牙周组织的效果并不理想，这可能是PDLSC所处的炎症微环境影响其命运所致。因此，本文将从信号通路方面，探讨炎症微环境对PDLSC成骨分化潜能的影响，为其应用于牙槽骨的再生修复提供理论依据。

关键词: 牙周炎, 牙周膜干细胞, 炎症微环境, 成骨分化, 信号通路

Abstract: Periodontal ligament stem cells (PDLSCs) used in tissue engineering is one of the most promising methods for the treatment of periodontitis with bone loss. However, the effect of PDLSCs in vivo for periodontal tissue regeneration is not ideal, which may be due to the influence of the inflammatory microenvironment of PDLSCs on their fate. Therefore, this review will explore the effect of inflammatory microenvironment on the osteogenic differentiation potential of PDLSCs from the aspect of signal pathway, so as to provide theoretical basis for the prevention and treatment strategy of bone loss in periodontitis.

Key words: periodontitis, periodontal ligament stem cell, inflammatory microenvironment, osteogenesis differentiation, signaling pathways

骆姝含张岚黄定明. 炎症微环境影响牙周膜干细胞成骨分化的信号通路[J]. 口腔生物医学, 2021, 12(2): 136-140.

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