SWELL1对细胞体积调控作用的研究进展

摘要/Abstract

摘要： 维持细胞体积的稳态是细胞正常生命过程的重要条件。体积调节阴离子通道（VRAC）在其中发挥了重要的调控作用，可通过有机物质累积和无机离子交换，使细胞膜内外的渗透压达到平衡，调控细胞体积，参与神经系统、免疫系统、代谢和细胞迁移、增殖、凋亡等一系列生物和细胞活动中。富含亮氨酸的重复序列蛋白8A（LRRC8A，又称SWELL1）与其4个同源家族成员是一类重要的VRAC，对细胞体积的调控起重要作用。本文就有关SWELL1结构、对不同细胞体积调控作用及机制的研究进展做一系统综述。

关键词: 体积调节阴离子通道, SWELL1, 细胞体积调节

Abstract: Maintaining the stability of cell volume is an important condition in the process of cell life. Volume regulated anion channel (VRAC) plays an important role in regulating the osmotic pressure inside and outside the cell membrane through organic matter accumulation and inorganic ion exchange. VRAC regulates cell volume and participates in a series of biological and cellular activities such as nervous system, immune system, metabolism, cell migration, proliferation and apoptosis. Recently, studies have confirmed that leucine rich repeat containing protein 8A (IRRC8a, also known as Swell1) and its four homologous family members are an important VRAC and play an important role in the regulation of cell volume. In this paper, we reviewed the structure of Swell1,as well as its effect and mechanism on different cell volume regulation.

Key words: Volume-regulated anion channel, SWELL1, Cell volume regulation

唐嘉琪周亦凝代杰文. SWELL1对细胞体积调控作用的研究进展[J]. 口腔生物医学, 2021, 12(2): 128-131.

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