Abstract: Objective:?To evaluate the application effect of the new type of bioceramic root canal sealer C-Root SP on the apical extrusion rate and postobturation pain experience of C-Root SP and iRoot SP after root canal filling. Methods:?A total of 498 teeth referred for root canal treatment with irreversible pulpitis and periapical periodontitis were recruited. Patients were randomly distributed into 4 groups by randomized controlled trial with matched obturation technique: iRoot SP with single-cone technique, iRoot SP with warm vertical compaction technique, C-Root SP with single-cone technique, and C-Root SP with warm vertical compaction technique. Postoperative X-ray film evaluation was used to record the apical extrusion condition of sealers in each group. The postobturation pain experience of 4 groups of patients at 1, 3 and 7 days after root canal filling was recorded by means of return visit and score of visual analog scale (VAS), and the effect of sealers on postobturation pain was analyzed. Results:?The extrusive rate rates of iRoot SP and C-Root SP are 45.5% and 43.3%, respectively. There was no significant difference between the extrusive rate of the two sealers using the same filling technique,(P＞0.05). The overfilling rate of sealants in the teeth with apical lesions was higher than that of the teeth without apical lesions (P＜0.05); The rate of sealer extrusion in iRoot SP and C-Root SP with warm vertical compaction technique was higher than that in single-cone technique (P＜0.05); There was no significant difference in the occurrence and intensity of postoperative pain between the two sealers (P＞0.05); The intensity of postoperative pain in each group was mostly mild pain. Extrusion of the two sealers had no significant effect on postoperative pain (P＞0.05). Conclusions:?There was no significant difference in the rate of sealer extrusion and postoperative pain after root canal filling between C-Root SP and iRoot SP.