口腔生物医学 ›› 2023, Vol. 14 ›› Issue (1): 63-68.

• 综述 • 上一篇    

镁基生物材料表面涂层在生物医学中的应用

梁琛1,曲星源2,王雷3*   

  1. 1. 吉林大学口腔医院牙周科
    2. 吉林大学口腔医院
    3. 吉林大学口腔医院牙周病科
  • 收稿日期:2021-10-14 修回日期:2023-01-23 出版日期:2023-03-25 发布日期:2023-03-29
  • 通讯作者: 王雷 E-mail:wang_lei99@jlu.edu.cn
  • 基金资助:
    吉林省教育厅科学技术研究项目;吉林省科技发展计划项目

Application of surface coatings on magnesium based biomaterials in biomedicine.

  • Received:2021-10-14 Revised:2023-01-23 Online:2023-03-25 Published:2023-03-29

摘要: 镁基生物材料作为一种生物可降解材料,具有良好的机械强度、潜在的生物相容性、可降解性、骨传导性等特性,成为生物医用材料领域的研究热点。然而,这些材料在生理环境下的快速降解可能导致机械强度的过早丧失、皮下气肿和碱中毒等现象的发生,从而阻碍其在临床中的应用。学者们针对以上缺点,提出了许多表面处理策略,以抑制其降解速率,强化其生物活性,促进其生物相容性等相关性能。本文对近年来镁基材料表面功能化涂层的研究进展以及这些涂层在调节降解行为和生物功能方面的表现做一综述。

Abstract: As a potential biodegradable material, magnesium based biomaterials have good mechanical strength, potential biocompatibility, biodegradability, bone conductivity and other characteristics, which has become a research hotspot in the field of biomedical materials. However, the rapid degradation of these materials in the physiological environment may lead the loss of mechanical strength, subcutaneous emphysema and alkalosis, thus hindering their clinical application. In view of the above shortcomings, many surface treatment strategies have been proposed to inhibit its degradation rate and enhance its biological activity,biocompatibility and other related properties. In this paper, the research has reviewed the progress of functionalized coatings on the surface of magnesium based biomaterials and their performance in regulating degradation behavior and biological function in recent years .As a potential biodegradable material, magnesium based biomaterials have good mechanical strength, potential biocompatibility, biodegradability, bone conductivity and other characteristics, which has become a research hotspot in the field of biomedical materials. However, the rapid degradation of these materials in the physiological environment may lead the loss of mechanical strength, subcutaneous emphysema and alkalosis, thus hindering their clinical application. In view of the above shortcomings, many surface treatment strategies have been proposed to inhibit its degradation rate and enhance its biological activity,biocompatibility and other related properties. In this paper, the research has reviewed the progress of functionalized coatings on the surface of magnesium based biomaterials and their performance in regulating degradation behavior and biological function in recent years .