口腔生物医学 ›› 2025, Vol. 16 ›› Issue (3): 121-126.

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细胞外囊泡在神经退行性疾病及神经损伤中的应用

牛书田1,杨英芝1,徐赫伟1,吴乐楠1,任永正1,杨晓姗2,刘世宇2   

  1. 1. 空军军医大学基础医学院学员二大队七队
    2. 空军军医大学口腔医院
  • 收稿日期:2025-05-29 修回日期:2025-06-05 出版日期:2025-06-25 发布日期:2025-06-30
  • 通讯作者: 刘世宇 E-mail:liushiyu@fmmu.edu.cn
  • 基金资助:
    国家自然科学基

Applications of extracellular vesicles in neurodegenerative diseases and nerve injury

  • Received:2025-05-29 Revised:2025-06-05 Online:2025-06-25 Published:2025-06-30

摘要: 神经退行性疾病是中枢神经系统中一类因多种原因导致部分神经元功能丧失并最终死亡,进而引发相关功能缺失的疾病,包括阿尔茨海默病、帕金森病和肌萎缩侧索硬化症等。创伤或缺血等因素引起的神经损伤同样会导致神经功能障碍,对患者的生活质量造成严重影响。近年来,细胞外囊泡(EVs)凭借其独特的生物学特性,在神经退行性疾病治疗和神经损伤修复领域展现出巨大潜力。本文介绍了EVs的生物学特性,阐述其在神经退行性疾病治疗和神经损伤修复中的重要作用,旨在为相关领域的研究与临床应用提供参考。

Abstract: Neurodegenerative diseases (NDs) are a group of disorders in the central nervous system characterized by progressive neuronal dysfunction and death, leading to functional impairments, including Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis. Neural injuries caused by trauma or ischemia can also lead to neural dysfunction, severely affecting patients' quality of life. In recent years, extracellular vesicles (EVs) have demonstrated remarkable potential in the treatment of neurodegenerative diseases and neural injury repair due to their unique biological properties. This article introduces the biological characteristics of EVs and their critical roles in the treatment of neurodegenerative diseases and neural injury repair, aiming to provide valuable insights for future research and clinical applications in this field.