转录因子EB通过调节自噬溶酶体途径在炎症性疾病中的作用及研究进展

摘要/Abstract

摘要： 自噬溶酶体途径是细胞降解功能失调蛋白和细胞器的主要机制，在细胞内环境的稳定和应对外界应激中起着关键作用。转录因子EB作为自噬和溶酶体生物发生的主要调节剂，能够激活一系列与溶酶体和自噬有关的基因，这不仅促进了溶酶体的生成和功能，也加强了自噬体的形成和自噬降解效率，这使得其在多种炎症性疾病中发挥关键作用，比如骨关节炎、动脉粥样硬化、胰腺炎、炎症性肠病和口腔炎症性疾病等。本文重点总结了TFEB的功能及其在炎症性疾病发生发展中的调节作用，为靶向疾病的治疗提供进一步的思路。

关键词: 噬溶酶体途径, 转录因子EB, 炎症性疾病

Abstract: The autophagy-lysosomal pathway (ALP) serves as the primary cellular mechanism for the degradation of dysfunctional proteins and organelles, playing a pivotal role in maintaining intracellular homeostasis and in the cell's response to external stressors. Transcription Factor EB (TFEB), known as a master regulator of autophagy and lysosomal biogenesis, is increasingly recognized in the pathology of various inflammatory conditions. It exerts its influence by activating a suite of genes associated with autophagy, thus not only enhancing the formation and function of lysosomes but also improving the efficiency of autophagosome formation and degradation. This modulation is particularly significant in diseases such as osteoarthritis, atherosclerosis, pancreatitis, inflammatory bowel diseases, and oral inflammatory diseases. In this article, we highlight the critical functions of TFEB and explore its regulatory role in the etiology of inflammatory diseases, offering novel insights and potential therapeutic targets for the development of targeted treatments.

Key words: autophagy-lysosomal pathway, transcription factor EB, inflammatory diseases

叶凤鸣蔡青. 转录因子EB通过调节自噬溶酶体途径在炎症性疾病中的作用及研究进展[J]. 口腔生物医学, 2025, 16(3): 165-170.

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