Abstract: Objective：To investigate the effects of SFCS nerve conduits on repairing facial nerve defect in rabbits by transplantation. Methods：Twenty-one male rabbits were made into models with 8 mm gaps on both sides of buccal branches of the facial nerve. SFCS nerve conduits were used to repair the right gaps of facial nerve, regarded as the experimental group. Autologous nerve were grafted into the left gaps, regarded as the control group. Electrophysilogical examination of nervous system was performed 4, 6, 8 weeks after operation, and general observation was done with microscope 2,4,6,8 weeks after operation. HE and Toluidine blue staining histological examination were performed, and image analysis system was used to analyze images. Results：The conduction velocity of the facial nerve﹝(27.50±3.00)m/s﹞, the counts of axon per unit area(741.80±49.92), and the thickness of the myelin sheath﹝(12.71±0.42)pm﹞of rabbits in experimental group were not statistically different with those in control group（P＞0.05）. Conclusions：The SFCS nerve conduits can effectively promote axon regeneration of rabbit facial nerve. They can potentially be used as a substitute for autografts to repair nerve defects.