›› 2012, Vol. 3 ›› Issue (3): 132-134.

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Expression of survivin and its relationship with the expression of caspase-3 and p53 proteins in odontogenic keratocysts

  

  • Received:2012-07-25 Revised:2012-08-15 Online:2012-09-25 Published:2012-10-08
  • Contact: Yong HU E-mail:huyong8044@yahoo.cn

Abstract: Objective:To investigate the expression of apoptosis-associated protein Survivin in human odontogenic keratocyst (OKC) and its relationship with the expression of Caspase-3 and p53. Methods:TUNEL was used to detect the distribution of apoptotic cells in OKC. Immunohistochemical assay was used to detect the expression of Survivin, Caspase-3, p53 proteins in 40 cases of OKC ( including 20 cases of primary OKC, 20 cases of recurrent OKC). Results:Apoptotic cells were mainly seen in cells of surface layer of OKC epithelial lining . Survivin positive staining was mainly in basal and suprabasal layer cells of 26(65%)cases, Caspase-3 positive staining were mainly in surface epithelial cells of 18(45%)cases. The expression of p53 was negative in OKC of all cases. Conclusions:Apoptosis-associated protein Survivin and Caspase-3 play an important role in generation and development of OKC.

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