Abstract: Abstract: Objective To evaluate the wear resistant of heat-cured base resin to three mechanical denture cleaning. Methods 64 samples were made, 60 of which were divided into 4 groups. Then, 3 groups were cleaned with three mechanical cleaning methodes separately. After cleaning, each group were divided into 3 subgroups to immerse into orange juice , dentilave or medicinal wine for 4 weeks. Baseline color was measured using a colorimeter. Further color measurements were made after 4 weeks of immersion. Compared ΔE with the results using a one-way ANOVA. The other 4 samples were made to observe by Electron microscopic. Results The mechanical cleaning have no effects on acceleration resin’s staining (P﹥0.05) except cleaning by tooth paste; cleaning by tooth paste showed wear on base resin, while cleaning with water and dental paste without wear effect. Conclusions Dentipur showed no wear on the heat-cured base resin, and did not acceleration resin’s staining. But thooth paste did.