›› 2014, Vol. 5 ›› Issue (1): 11-14.

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Expression of Osteopontin and CD44v6 and their significance in keratocystic odontogenic tumor before and after decompression

  

  • Received:2014-01-17 Revised:2014-03-11 Online:2014-03-25 Published:2014-03-31

Abstract: Objective:To investigate the expression of osteopontin (OPN) and CD44v6 and their significance in keratocystic odontogenic tumor (KCOT) before and after decompression. Methods:All 16 pairs of paraffin- embedded tissue specimens of KCOT before and after decompression were collected and then used for immunohistochemical detection of OPN and CD44v6. The results were statistically analyzed. Results:The expression of OPN in KCOT was down-regulated after decompression(P<0.05).And CD44v6 expression in postoperative KCOT epithelium was significantly less than that in preoperative KCOT epithelium(P<0.05). Conclusions:The local aggressive behavior of KCOT epithelium after decompression was decreased, which may be part of the mechanisms of decompression therapy.