›› 2016, Vol. 7 ›› Issue (3): 122-128.

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The effects of parathyroid hormone on proliferation and apoptosis ability of bone marrow mesenchymal stem cells in ovariectomized rats

  

  • Received:2016-06-28 Revised:2016-08-31 Online:2016-09-25 Published:2016-09-28

Abstract: Objective:To investigate the effects of parathyroid hormone (PTH) on proliferation and apoptosis ability of bone marrow mesenchymal stem cells (BMMSCs) from ovariectomized(OVX)rats. Methods:An ovariectomized animal model wasadopted. The rats were treated with either subcutaneous PTH or normal saline. The proliferation and apoptosis of BMMSCs were detected by means of flow cytometry. Results:The S-phase fraction of BMMSC in ovariectomized with PTH treatment group (8.87±0.11)% was significantly increased when compared with ovariectomized group(5.23±0.20)%. And the apoptosis of BMMSC in ovariectomized with PTH treatment group(4.17±0.15)% was significantly reduced when compared with ovariectomized group(8.13±0.61)%. Conclusions:Intermittent application of PTH can strengthen the proliferation ability of BMMSCs from OVXrats but suppress the apoptosis.