Abstract: Objective: To tackle the dimensional shrinkage of electrospun membrane of (poly(lactic-co-glycolic acid), PLGA) by adding a certain amount of (poly(ε-caprolactone), PCL)in order to make it qualify for clinical usewith the biocompatibility of PLGA not significantly affected. Methods: We blended PLGA and PCL in different weight ratio (10:0, 7:3, 6:4, 5:5 and 0:10), and fibrous membranes were collected by electrospun. The diameters and shrinkage of the fibers were compared. The biocompatibilities of different membranes were compared by culturing osteoblasts under the same condition on them. The topography of the membranes and the morphology of the cells adherent on different membranes were observed with scanning electron microscope. Results: The diameter of electrospun fibers rose as the ratio of PCL increased, but the topography of the membranes and the morphology of the cells adherent on them presented no significant diversity among different PLGA/PCL ratio. The biocompatibility of PLGA declined with the adding of PCL, and different blending groups (7:3, 6:4, 5:5) showed no statistical differences, but they were still better than PCL. PLGA electrospun membranes showed significant shrinkage in phosphate buffer solution, and the dimensional shrinkage decreased with the addition of PCL, but the decrease presented no significant differences among different PLGA/PCL ratio. Conclusions: Blending PLGA/PCL at a certain ratio can prominently ameliorate the shrinkage of PLGA, furthermore, the blending has little influence on the excellent biocompatibility of PLGA.