›› 2017, Vol. 8 ›› Issue (1): 32-36.

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The progress in molecular genetics of orofacial clefting

  

  • Received:2017-02-28 Revised:2017-03-08 Online:2017-03-25 Published:2017-04-11

Abstract: Orofacial clefts (OFCs) are the commonest craniofacial birth defects in human which are caused by the interaction between environmental and genetic factors. Most OFCs are non-syndromic (NS) cases in which clefting occurs as the only malformation in the affected infant. Although previous studies of linkage and candidate genes, and more recently, several genome-wide association studies (GWAS), have reported multiple candidate genes and chromosomal regions associated with NSOFC, the underlying genetic architecture of this birth defect remains largely unknown. This paper reviewed the progress in molecular genetics of orofacial clefting.