Abstract: Objective: The objectives of this study were to develop the first NACP rechargeable orthodontic cement, and investigate the effects of recharge duration and frequency on ion re-release efficacy. Methods: The rechargeable cement consisted of pyromellitic glycerol dimethacrylate (PMGDM) and ethoxylated bisphenol-A dimethacrylate (EBPADMA). NACP were mixed into the resin at 40% by mass. Specimens were tested for orthodontic bracket shear bond strength (SBS) to enamel, Ca and P ion initial release was tested in pH 4 solution. After the ions were exhausted, the specimens were recharged in pH 7 solution and re-release in pH 4 solution again. The re-release of the ions were recorded. Results: The new orthodontic cement had SBS similar to commercial orthodontic cement without CaP release (p > 0.1). Specimens after one recharge treatment (e.g., 1 minute immersion in recharge solution repeating 3 times in one day, referred to as 1 min 3 times) had substantial release of Ca and P ions continuously for 14 d without further recharge. The ion re-release did not decrease with increasing the number of recharge/re-release cycles (p > 0.1). The ion re-release concentrations at 14 d versus various recharge treatments were: 1 min 3 times > 3 min 2 times > 1 min 2 times > 6 min 1 time > 3 min 1 time > 1 min 1 time. Conclusions: The present study developed the first orthodontic cement with Ca and P ion recharge and long-term release capability. This NACP rechargeable orthodontic cement is promising to inhibit enamel demineralization and WSL around orthodontic brackets.