Abstract: Objective：To evaluate the bond strength of eighth generation adhesive-Single Bond Universal to glass ceramic and resin. Methods: 40 polished and ultrasound cleaned glass ceramics were divided randomly into 4 groups, and followed by different surface treatments: the control without any treatment, silane coupling treatment, hydrofluoric acid etching treatment, and the combination of silane coupling and hydrofluoric acid etching treatment. Each treatment has 10 glass ceramics and covered with Single Bond Universal. Test pieces were made of resin. The test pieces were thermocycled 5000 times and stored in distilled water at 37℃ for 24h before shear bond strength test by universal testing machine. Specimens were also evaluated for mode of fracture using scanning electron microscope (SEM) analysis. Results: The shear bond strength were significantly higher under the hydrofluoric acid etching treatment and the combination treatment than that under the control treatment and the hydrofluoric acid etching treatment, and no statistic difference was found between the hydrofluoric acid etching treatment and the combination treatment. For the mode of fracture, cohesive failure and mixing failure were the main mode under the hydrofluoric acid etching treatment and the combination treatment. Conclusions: When using Single Bond Universal to repair the fracture of the glass ceramic, strong bonding effect will achieve even without silane coupling agent. This might provide the theory basis for the repair of the fractured glass ceramic with resin in clinics.